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• W2273033861 abstract "There is growing evidence that in Crohn’s disease the achievement and maintenance of mucosal healing (MH) through anti-TNFα antibodies may change the natural history of the disease. Few studies evaluating such outcome as a therapeutic goal are available in paediatrics. The primary aim of the study was to assess the efficacy of biologics in obtaining MH in a paediatric Crohn’s disease cohort. The secondary aims were: (1) to assess response based on early or late treatment introduction and on combination therapy with immunomodulators versus biologics alone; and (2) to evaluate clinical outcome 2 years after the second endoscopy. Biologic-naive paediatric Crohn’s disease patients starting anti-tumour necrosis factor α (TNFα) treatment were enrolled. Patients’ demographic and treatment data were recorded. Clinical [Pediatric Crohn’s Disease Activity Index (PCDAI)] and endoscopic [Simple Endoscopic Score for Crohn’s Disease (SES-CD)] evaluations were performed at time 0 (T0) and after 9–12 months (follow-up). Appropriate induction and maintenance therapeutic schemes were applied. Results: Thirty-seven patients were enrolled. At enrolment, mean age was 12.3 ± 3.4 years and mean disease duration was 13.0 ± 16 months. At follow-up there was a significant decrease in PCDAI and SES-CD compared with T0 ( p < 0.01). No statistical difference in frequency of MH between the early and late treatment introduction groups was found. Combination therapy was superior in obtaining complete plus partial MH ( p < 0.01). One and 2 years after the second endoscopy, all and 79% of patients with complete MH and 75 and 67% of those with partial MH were still in clinical remission, respectively. Conclusions: Biologics improve mucosal lesions, apparently more effectively if given in combination with immunomodulators. MH appears to sustain a better disease course." @default.
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• W2273033861 date "2015-07-17" @default.
• W2273033861 modified "2023-09-29" @default.
• W2273033861 title "Prospective Evaluation of the Achievement of Mucosal Healing with Anti-TNF-α Therapy in a Paediatric Crohn’s Disease Cohort" @default.
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• W2273033861 doi "https://doi.org/10.1093/ecco-jcc/jjv126" @default.
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