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• W2273048610 abstract "Thirty-eight patients were treated with cefamandole 6–12 g/d. These included 24 patients with cellulitis and/or abscess and 14 with osteomyelitis or septic arthritis. Two patients were bacteremic. Of the patients treated, 26 had an underlying disease; 27 required some surgical procedure. Staphylococcus aureus was the most frequent bacteria isolated. Of 38 patients treated, 31 had a clinical cure, six were unevaluable, and one failed on therapy. Twelve patients developed a reaction to the drug. Average peak serum level after cefamandole 1 g iv was 30.6 μ g/ml (range, 10–67 μ g/ml); average peak serum level after 2 g iv was 39.9 μ g/ml (range, 6.6–110 μ g/ml). Cancellous bone concentrations in two patients ranged from 6 to 7 μ g/ml, and cortical bone concentrations in five patients ranged from 10 to 28 μ g/ml." @default.
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• W2273048610 date "1981-12-01" @default.
• W2273048610 modified "2023-10-06" @default.
• W2273048610 title "Use of Cefamandole in the Treatment of Soft Tissue and Skeletal Infections" @default.
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• W2273048610 doi "https://doi.org/10.1177/106002808101501206" @default.
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