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• W2273060742 abstract "Targeted disruption of the transforming growth factor-beta 1 (TGF-beta 1) gene in mice results in the development of a massive multifocal inflammatory disease in many tissues. Because no detectable pathogen was identified, we examined whether autoimmune mechanisms played a role in initiating or maintaining the inflammatory disease. The serum of TGF- beta 1 knockout mice contained elevated titers of antibodies to nuclear antigens (ssDNA, dsDNA, Sm, and RNP) as well as reactivity against the 16/6 idiotype (16/6 Id). In addition, Ig deposits were detected in renal glomeruli of TGF- beta 1 knockout mice. Transplantation of TGF- beta 1 knockout hematopoietic cells into normal irradiated recipients resulted in a similar profile of autoantibody production as well as in the induction of inflammatory lesions. Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent." @default.
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• W2273060742 date "1996-02-15" @default.
• W2273060742 modified "2023-10-07" @default.
• W2273060742 title "Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse" @default.
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• W2273060742 doi "https://doi.org/10.1182/blood.v87.4.1439.bloodjournal8741439" @default.
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