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- W227314941 abstract "We previously identified an HIV-1 fusion inhibitor P20A targeting HIV-1 gp41 6-HB fusion core. Using alanine scanning mutagenesis, we investigated the effect of 6-HB surface residue mutations on the binding affinity between P20A and 6-HB. Substitution of positively or negatively charged residues in the distal region of 6-HB with alanines resulted in significant decrease or increase of its binding affinity to P20A, respectively. The 6-HB with E630K, D632K, or E634K mutation exhibited enhanced binding affinity with P20A, suggesting that P20A blocks HIV-1 fusion through electrostatic interaction with the positively charged residues in the distal region of the gp41 fusion core." @default.
- W227314941 created "2016-06-24" @default.
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- W227314941 date "2015-09-01" @default.
- W227314941 modified "2023-10-16" @default.
- W227314941 title "P20A inhibits HIV-1 fusion through its electrostatic interaction with the distal region of the gp41 fusion core" @default.
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- W227314941 doi "https://doi.org/10.1016/j.micinf.2015.05.003" @default.
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