Matches in SemOpenAlex for { <https://semopenalex.org/work/W2273152044> ?p ?o ?g. }
- W2273152044 endingPage "e0147432" @default.
- W2273152044 startingPage "e0147432" @default.
- W2273152044 abstract "In a recent study, we reported that a recombinant protein from fusion expression of flagellin to porcine circovirus type 2 (PCV2) Cap induced robust humoral and cell-mediated immunity that afforded full protection for PCV2 infection using BALB/c mice. Here, we further evaluated the immunogenicity and protection of the recombinant protein using specific pathogen free (SPF) pigs. Twenty-five 3-week-old piglets without passively acquired immunity were divided into 5 groups. All piglets except negative controls were challenged with a virulent PCV2 at 21 days after booster vaccination and necropsied at 21 days post-challenge. Vaccination of piglets with the recombinant protein without adjuvant induced strong humoral and cellular immune responses as observed by high levels of PCV2-specific IgG antibodies and neutralizing antibodies, as well as frequencies of PCV2-specific IFN-γ-secreting cells that conferred good protection against PCV2 challenge, with significant reduced PCV2 viremia, mild lesions, low PCV2 antigen-positive cells, as well as improved body weight gain, comparable to piglets vaccinated with a commercial PCV2 subunit vaccine. These results further demonstrated that the recombinant flagellin-Cap fusion protein is capable of inducing solid protective humoral and cellular immunity when administered to pigs, thereby becoming an effective PCV2 vaccine candidate for control of PCV2 infection." @default.
- W2273152044 created "2016-06-24" @default.
- W2273152044 creator A5000469577 @default.
- W2273152044 creator A5017215800 @default.
- W2273152044 creator A5021119678 @default.
- W2273152044 creator A5029553601 @default.
- W2273152044 creator A5035471284 @default.
- W2273152044 creator A5036803265 @default.
- W2273152044 creator A5037677450 @default.
- W2273152044 creator A5046210257 @default.
- W2273152044 creator A5050066817 @default.
- W2273152044 creator A5078386976 @default.
- W2273152044 creator A5089205285 @default.
- W2273152044 date "2016-02-05" @default.
- W2273152044 modified "2023-09-25" @default.
- W2273152044 title "Immunity Elicited by an Experimental Vaccine Based on Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein in Piglets" @default.
- W2273152044 cites W1664413187 @default.
- W2273152044 cites W1813135772 @default.
- W2273152044 cites W1967256901 @default.
- W2273152044 cites W1973020747 @default.
- W2273152044 cites W1973036477 @default.
- W2273152044 cites W1975972985 @default.
- W2273152044 cites W1989295132 @default.
- W2273152044 cites W2002924510 @default.
- W2273152044 cites W2003557538 @default.
- W2273152044 cites W2003732493 @default.
- W2273152044 cites W2004808660 @default.
- W2273152044 cites W2006153115 @default.
- W2273152044 cites W2007074963 @default.
- W2273152044 cites W2009484599 @default.
- W2273152044 cites W2010651154 @default.
- W2273152044 cites W2012713635 @default.
- W2273152044 cites W2016490570 @default.
- W2273152044 cites W2026577124 @default.
- W2273152044 cites W2030730294 @default.
- W2273152044 cites W2033118085 @default.
- W2273152044 cites W2035108540 @default.
- W2273152044 cites W2041146694 @default.
- W2273152044 cites W2042449172 @default.
- W2273152044 cites W2046182783 @default.
- W2273152044 cites W2048002928 @default.
- W2273152044 cites W2049069390 @default.
- W2273152044 cites W2056445313 @default.
- W2273152044 cites W2059866651 @default.
- W2273152044 cites W2067541106 @default.
- W2273152044 cites W2082919689 @default.
- W2273152044 cites W2089460897 @default.
- W2273152044 cites W2094156747 @default.
- W2273152044 cites W2096536485 @default.
- W2273152044 cites W2098918106 @default.
- W2273152044 cites W2100072399 @default.
- W2273152044 cites W2100801019 @default.
- W2273152044 cites W2106120695 @default.
- W2273152044 cites W2106510584 @default.
- W2273152044 cites W2111970919 @default.
- W2273152044 cites W2119106002 @default.
- W2273152044 cites W2121254917 @default.
- W2273152044 cites W2121531174 @default.
- W2273152044 cites W2123633951 @default.
- W2273152044 cites W2136778970 @default.
- W2273152044 cites W2147997790 @default.
- W2273152044 cites W2153314219 @default.
- W2273152044 cites W2162656620 @default.
- W2273152044 cites W2163451350 @default.
- W2273152044 cites W2163744970 @default.
- W2273152044 cites W2163816719 @default.
- W2273152044 cites W2165426944 @default.
- W2273152044 cites W2169197920 @default.
- W2273152044 cites W2337194518 @default.
- W2273152044 cites W2401399907 @default.
- W2273152044 cites W2409505284 @default.
- W2273152044 cites W4296816736 @default.
- W2273152044 doi "https://doi.org/10.1371/journal.pone.0147432" @default.
- W2273152044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4746120" @default.
- W2273152044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26848967" @default.
- W2273152044 hasPublicationYear "2016" @default.
- W2273152044 type Work @default.
- W2273152044 sameAs 2273152044 @default.
- W2273152044 citedByCount "16" @default.
- W2273152044 countsByYear W22731520442016 @default.
- W2273152044 countsByYear W22731520442017 @default.
- W2273152044 countsByYear W22731520442018 @default.
- W2273152044 countsByYear W22731520442019 @default.
- W2273152044 countsByYear W22731520442021 @default.
- W2273152044 countsByYear W22731520442022 @default.
- W2273152044 crossrefType "journal-article" @default.
- W2273152044 hasAuthorship W2273152044A5000469577 @default.
- W2273152044 hasAuthorship W2273152044A5017215800 @default.
- W2273152044 hasAuthorship W2273152044A5021119678 @default.
- W2273152044 hasAuthorship W2273152044A5029553601 @default.
- W2273152044 hasAuthorship W2273152044A5035471284 @default.
- W2273152044 hasAuthorship W2273152044A5036803265 @default.
- W2273152044 hasAuthorship W2273152044A5037677450 @default.
- W2273152044 hasAuthorship W2273152044A5046210257 @default.
- W2273152044 hasAuthorship W2273152044A5050066817 @default.
- W2273152044 hasAuthorship W2273152044A5078386976 @default.
- W2273152044 hasAuthorship W2273152044A5089205285 @default.
- W2273152044 hasBestOaLocation W22731520441 @default.