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• W2273214660 abstract "Toll-like receptors (TLRs), key initiators of innate immune responses, recognize antigens and are essential in linking innate and adaptive immune responses. Misrecognition and over-stimulation/expression of TLRs may contribute to the development of chronic inflammatory diseases and autoimmune diseases. However, appropriate and mature TLR responses are associated with the establishment of resistance against some infectious diseases. In this study, we assessed the mRNA expression profile of TLRs 1–10 in splenic and ileal mononuclear cells (MNCs) and dendritic cells (DCs) of germ-free (GF) and conventional pigs at different ages. We found that the TLR mRNA expression profiles were distinct between GF and conventional pigs. The expression profiles were also significantly different between splenic and ileal MNCs/DCs. Comparison of the TLR expression profiles in GF and conventional newborn and young pigs demonstrated that exposure to commensal microbiota may play a more important role than age in TLR mRNA expression profiles. To our knowledge, this is the first report that systematically assesses porcine TLRs 1–10 mRNA expression profiles in MNCs and DCs from GF and conventional pigs at different ages. These results further highlighted that the commensal microbiota of neonates play a critical role through TLR signaling in the development of systemic and mucosal immune systems." @default.
• W2273214660 created "2016-06-24" @default.
• W2273214660 creator A5023833842 @default.
• W2273214660 creator A5037626152 @default.
• W2273214660 creator A5064559752 @default.
• W2273214660 creator A5073496590 @default.
• W2273214660 creator A5084442629 @default.
• W2273214660 date "2016-03-01" @default.
• W2273214660 modified "2023-09-26" @default.
• W2273214660 title "Tissue-specific mRNA expression profiles of porcine Toll-like receptors at different ages in germ-free and conventional pigs" @default.
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• W2273214660 doi "https://doi.org/10.1016/j.vetimm.2016.01.008" @default.
• W2273214660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4788813" @default.
• W2273214660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26964712" @default.
• W2273214660 hasPublicationYear "2016" @default.
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