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• W2273222023 abstract "A series of new indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3 triazoles (I1–I6 and I7–I12) were synthesized and screened for their anticancer (in vitro and in vivo), antibacterial, and DNA cleavage activities. All the synthesized compounds were characterized by spectral studies. The in vitro anticancer screening results revealed that compound I12 has registered potential activity against MCF-7, HeLa and HEK293 as compared with the standard reference drug Cisplatin. Remaining compounds have exhibited moderate to good activity against three cancer cell lines. The antibacterial activity screening results revealed that compounds, I6 and I12 have registered excellent inhibition against Escherichia coli and Bacillus subtilis in comparison with the standard drug Streptomycin. Compounds I2 and I11 have partially cleaved the DNA at 100 μg mL−1 concentration." @default.
• W2273222023 created "2016-06-24" @default.
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• W2273222023 date "2016-03-01" @default.
• W2273222023 modified "2023-10-02" @default.
• W2273222023 title "Indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3-triazoles: Synthesis, characterization and evaluation of anticancer, antibacterial, and DNA-cleavage activities" @default.
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• W2273222023 doi "https://doi.org/10.1016/j.bmcl.2016.01.055" @default.
• W2273222023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26873415" @default.
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