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• W2273257870 startingPage "789" @default.
• W2273257870 abstract "Aims: As data on the use of circulating tumor cells (CTCs) to predict patient outcomes in extensive-stage small-cell lung cancer (ES-SCLC) remain inconclusive, we investigated the clinical value of CTC determination in an open-label, multicenter study of 91 patients with newly diagnosed ES-SCLC. Materials & methods: Blood CTC counts were determined using the CellSearch ® system at baseline, after the second cycle of chemotherapy, and on disease progression. Results & conclusion: Following the second cycle of treatment, CTC numbers and the change in CTCs were strong, significant and independent indicators for both progression-free survival and overall survival in ES-SCLC. The CTC change was associated with both refractory disease (response to initial therapy ≤3 months) and sensitive disease (response to initial therapy >3 months)." @default.
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• W2273257870 date "2016-03-01" @default.
• W2273257870 modified "2023-10-18" @default.
• W2273257870 title "Circulating tumor cell counts/change for outcome prediction in patients with extensive-stage small-cell lung cancer" @default.
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• W2273257870 doi "https://doi.org/10.2217/fon.15.346" @default.
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