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- W2273331370 abstract "Ocular drug delivery formulations must meet anatomical, biopharmaceutical, patient-driven and regulatory requirements. Mucoadhesive polymers can serve as a better alternative to currently available ophthalmic formulations by providing improved bioavailability. If all requirements are addressed, a polymeric formulation resembling the tear film of the eye might be the best solution. The optimum formulation must not have high osmotic activity, should provide appropriate surface tension, pH and refractive index, must be non-toxic and should be transparent and mucoadhesive. We would like to highlight the importance of in vitro polymer testing from a pharmaceutical aspect. We, therefore, carried out physical–chemical investigations to verify the suitability of certain systems for ophthalmic formulations. In this work, in situ gelling, mucoadhesive thiolated poly(aspartic acid)s were tested from ophthalmic formulation aspects. The results of preformulation measurements indicate that these polymers can be used as potential carriers in ophthalmic drug delivery." @default.
- W2273331370 created "2016-06-24" @default.
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- W2273331370 date "2015-12-07" @default.
- W2273331370 modified "2023-10-18" @default.
- W2273331370 title "<i>In vitro</i> testing of thiolated poly(aspartic acid) from ophthalmic formulation aspects" @default.
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- W2273331370 doi "https://doi.org/10.3109/03639045.2015.1118497" @default.
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