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- W2273433166 abstract "[Objective] To observe the bidirectional adjusting effect of c-Myc ASODN to the proliferation of human hepatoma Bel-7402 cell and discuss the biological function of c-Myc proto-oncogene. [Methods] Bel-7402 cells was incubated with c-Myc ASODN only or combined with berberine, The cell growth inhibitory rates were evaluated by cells counting after typan blue staining and CCK-8 agent, IC50 was calculated according to the growth inhibitory rates. [Results] The proliferation of Bel-7402 cells wee obviously inhibited when only stimulated by c-Myc ASODN or berberine, respectively. While combined use, the inhibitory effect became significantly weaken compared with berberine group (P＜0.05). [Conclusion] c-Myc gene imposed different adjusting effects on cell proliferation in different environment: accelerate cell proliferation under advantageous conditions and inhibit cell proliferation under adverse circumstances, c-Myc ASODN antagonized c-Myc's physiological function through down-regulate expression of c-Myc proto-oncogene and shown different effects according to different culture circumstances. Moreover, c-Myc ASODN obviously down-regulated the sensitivity of Bel-7402 cells to berberinE." @default.
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- W2273433166 date "2005-06-30" @default.
- W2273433166 modified "2023-09-24" @default.
- W2273433166 title "Bidirectional Adjusting Effect of c-Myc ASODN on Proliferation of Human Hepatoma Bel-7402 Cell Line" @default.
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