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- W2273453984 abstract "The antioxidant activities and inhibitory activities against angiotensin converting enzyme (ACE) and semicarbazide-sensitive amine oxidase of monohydroxamates of aspartic acid and glutamic acid (L-aspartic acid ?-hydroxamate, AAH; L-glutamic acid ?-hydroxamate, GAH) were investigated in this thesis.. From the results of DPPH scavenging activities, it was found that both AAH and GAH exhibited dose-dependent scavenging activities, and the IC50 was 36 ?M and 48 ?M, respectively. For superoxide radical scavenging activities by the NADH-PMS generating system, the IC50 was 18.99 mM and 6.33 mM, respectively; and by xanthine/xanthine oxidase generating system, the IC50 was 15.3 mM and 7.25 mM, respectively. For hydroxyl radical scavenging activities by the Fenton reaction and detected by electron spin resonance (ESR), the IC50 was 0.66 mM and 1.21 mM, respectively. Both AAH and GAH exhibited dose-dependent antioxidant activities against peroxynitrite-mediated dihydrorhodamine 123 oxidation, and protection roles against calf thymus DNA oxidation and Cu2+-mediated LDL oxidation. However, both asparagines and glutamine were not found to have above-mentioned antioxidant activities. For ACE inhibitory activity, it was found that both AAH and GAH exhibited dose-dependent ACE inhibitory activities in vitro, and the IC50 was 4.92 mM and 6.56 mM, respectively (against 20 mU ACE). From the results of kinetic analysis, it was found that the AAH exhibited competitive inhibition against FAPGG, and the Ki was 2.20 mM. For antihypertension experiment in vivo, the spontaneously hypertensive rats (SHR) were used to measure the blood pressure (24 hs) after one oral administration of AAH (2 mg/kg B.W and 5 mg/kg B.W). It was found that the lowest blood pressure was reached at the 6th hour after one oral administration. For systolic blood pressure (SBP), there were 37.8 mmHg and 30 mmHg reductions, respectively; for 2 mg AAH/kg B.W. and 5 mg AAH/kg B.W. For diastolic blood pressure (DBP), there were 42.19 mmHg and 35.71 mmHg reductions, respectively, for 2 mg AAH/kg B.W and 5 mg AAH/kg B.W. The positive control values of captopril (2 mg/kg B.W), there were 21.7 mmHg and 32.14 mmHg reductions, respectively, for SBP and DBP. For SSAO (from bovine plasma) inhibitory activities, it was found that both AAH and GAH exhibited dose-dependent SSAO inhibitory activities, and the IC50 was 0.7 mM and 0.023 mM, respectively. The SSAO inhibitory activity was confirmed by SSAO activity stains." @default.
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- W2273453984 date "2005-01-01" @default.
- W2273453984 modified "2023-09-27" @default.
- W2273453984 title "天門冬胺酸及麩胺酸的羥?胺酸衍生物其生理活性功能之探討-----抗氧化、抑制血管收縮素轉換酵素和Semicarbazide - Sensitive Amine Oxidase" @default.
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