FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2273649135> ?p ?o ?g. }

• W2273649135 endingPage "2480" @default.
• W2273649135 startingPage "2475" @default.
• W2273649135 abstract "The present study aimed to evaluate the effects of lysine‑specific demethylase 1 (LSD1) downregulation, induced by small interfering RNA (siRNA) transfection, on the proliferation, colony formation, migration and invasion of the papillary thyroid carcinoma K1 cell line. The siRNA targeting LSD1 and scrambled non‑targeting siRNA were each transfected into papillary thyroid carcinoma K1 cells. Downregulation of LSD1 mRNA and protein level was evaluated by reverse transcription‑quantitative polymerase chain reaction, and immunocytochemical (ICC) analysis and western blotting, respectively. A Cell Counting kit‑8 assay was applied to estimate the effect of LSD1‑siRNA on cell growth. Migration and invasion abilities were estimated by Transwell chamber assay. A soft agar colony formation assay was performed to estimate the effect of LSD1‑siRNA on tumorigenicity in vitro. ICC data showed that LSD1 protein was strongly expressed in the blank and control K1 cells compared with the LSD1‑siRNA cells (F=15.192, P<0.01). Compared with the control cells, cells transfected with siRNA targeting LSD1 exhibited significant downregulation of LSD1 mRNA (t=6.845, P<0.01) and protein (F=53.764, P<0.01) levels. siRNA targeting LSD1 also downregulated cell proliferation following transfection for 24, 48 and 72 h (t=4.777, P<0.001; t=3.302, P=0.003; and t=3.017, P=0.006, respectively). Compared with the control group, the amount of cell invasion was gradually reduced in the LSD1‑siRNA group (t=12.301, P<0.01). The number of migrating cells was significantly higher in the negative control group compared with the LSD1‑siRNA group (t=7.911, P<0.01), and the ability of colony formation in the LSD1‑siRNA cells was notably reduced in the soft agar formation assay (t=3.612, P=0.005). siRNA targeting LSD1 efficiently inhibits the proliferation, colony formation, migration and invasion of papillary thyroid carcinoma K1 cells." @default.
• W2273649135 created "2016-06-24" @default.
• W2273649135 creator A5016948627 @default.
• W2273649135 creator A5024265456 @default.
• W2273649135 creator A5035969895 @default.
• W2273649135 creator A5053886902 @default.
• W2273649135 creator A5068274975 @default.
• W2273649135 date "2016-02-18" @default.
• W2273649135 modified "2023-10-16" @default.
• W2273649135 title "Downregulation of LSD1 suppresses the proliferation, tumorigenicity and invasion of papillary thyroid carcinoma K1 cells" @default.
• W2273649135 cites W1506544057 @default.
• W2273649135 cites W1544539327 @default.
• W2273649135 cites W1553007119 @default.
• W2273649135 cites W1965262464 @default.
• W2273649135 cites W1978025728 @default.
• W2273649135 cites W1980673831 @default.
• W2273649135 cites W1981259130 @default.
• W2273649135 cites W1987258383 @default.
• W2273649135 cites W1990196512 @default.
• W2273649135 cites W2000381156 @default.
• W2273649135 cites W2005253752 @default.
• W2273649135 cites W2016789999 @default.
• W2273649135 cites W2019712140 @default.
• W2273649135 cites W2036986058 @default.
• W2273649135 cites W2054621094 @default.
• W2273649135 cites W2055599358 @default.
• W2273649135 cites W2057920192 @default.
• W2273649135 cites W2061440500 @default.
• W2273649135 cites W2063841003 @default.
• W2273649135 cites W2069792474 @default.
• W2273649135 cites W2094422265 @default.
• W2273649135 cites W2098724902 @default.
• W2273649135 cites W2107277218 @default.
• W2273649135 cites W2116542352 @default.
• W2273649135 cites W2119530061 @default.
• W2273649135 cites W2120450507 @default.
• W2273649135 cites W2131752445 @default.
• W2273649135 cites W2149931953 @default.
• W2273649135 cites W2153107832 @default.
• W2273649135 cites W2158562032 @default.
• W2273649135 cites W2162683438 @default.
• W2273649135 cites W2165903435 @default.
• W2273649135 cites W2186876476 @default.
• W2273649135 cites W2192080449 @default.
• W2273649135 cites W2312844872 @default.
• W2273649135 cites W2396035051 @default.
• W2273649135 cites W2775769105 @default.
• W2273649135 cites W4211107646 @default.
• W2273649135 cites W4212766227 @default.
• W2273649135 cites W4233489284 @default.
• W2273649135 cites W591487134 @default.
• W2273649135 doi "https://doi.org/10.3892/ol.2016.4244" @default.
• W2273649135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4812116" @default.
• W2273649135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27073501" @default.
• W2273649135 hasPublicationYear "2016" @default.
• W2273649135 type Work @default.
• W2273649135 sameAs 2273649135 @default.
• W2273649135 citedByCount "4" @default.
• W2273649135 countsByYear W22736491352019 @default.
• W2273649135 countsByYear W22736491352020 @default.
• W2273649135 crossrefType "journal-article" @default.
• W2273649135 hasAuthorship W2273649135A5016948627 @default.
• W2273649135 hasAuthorship W2273649135A5024265456 @default.
• W2273649135 hasAuthorship W2273649135A5035969895 @default.
• W2273649135 hasAuthorship W2273649135A5053886902 @default.
• W2273649135 hasAuthorship W2273649135A5068274975 @default.
• W2273649135 hasBestOaLocation W22736491351 @default.
• W2273649135 hasConcept C104317684 @default.
• W2273649135 hasConcept C11957725 @default.
• W2273649135 hasConcept C121608353 @default.
• W2273649135 hasConcept C127561419 @default.
• W2273649135 hasConcept C134018914 @default.
• W2273649135 hasConcept C1491633281 @default.
• W2273649135 hasConcept C153911025 @default.
• W2273649135 hasConcept C185592680 @default.
• W2273649135 hasConcept C22615655 @default.
• W2273649135 hasConcept C2779013556 @default.
• W2273649135 hasConcept C2781018059 @default.
• W2273649135 hasConcept C29537977 @default.
• W2273649135 hasConcept C2993294228 @default.
• W2273649135 hasConcept C502942594 @default.
• W2273649135 hasConcept C526584372 @default.
• W2273649135 hasConcept C54009773 @default.
• W2273649135 hasConcept C54355233 @default.
• W2273649135 hasConcept C55493867 @default.
• W2273649135 hasConcept C62112901 @default.
• W2273649135 hasConcept C81885089 @default.
• W2273649135 hasConcept C86803240 @default.
• W2273649135 hasConceptScore W2273649135C104317684 @default.
• W2273649135 hasConceptScore W2273649135C11957725 @default.
• W2273649135 hasConceptScore W2273649135C121608353 @default.
• W2273649135 hasConceptScore W2273649135C127561419 @default.
• W2273649135 hasConceptScore W2273649135C134018914 @default.
• W2273649135 hasConceptScore W2273649135C1491633281 @default.
• W2273649135 hasConceptScore W2273649135C153911025 @default.
• W2273649135 hasConceptScore W2273649135C185592680 @default.
• W2273649135 hasConceptScore W2273649135C22615655 @default.
• W2273649135 hasConceptScore W2273649135C2779013556 @default.

• next