Matches in SemOpenAlex for { <https://semopenalex.org/work/W2273670116> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2273670116 abstract "Background: White matter lesions (WML) are associated with hypertension. Blood pressure (BP) is transmitted to the brain via the carotid arteries, and autoregulation helps protect the brain. We investigated if BP via carotid waveform parameters were associated with WML. Methods: We obtained BP measurements from a cohort of community dwelling subjects at mean ages 70±1 and 73±1 years; brain MRI and carotid artery ultrasound at mean age 73±1 years. We calculated mean values of BP (systolic, diastolic, mean, variability and pulsatility), measured WML by volume, and Fazekas scale. We calculated internal carotid artery (ICA) mean blood flow velocity, pulsatility index (PI), and resistivity index (RI). We tested associations between BP and ICA flow parameters and WML using multiple linear regression, corrected for intracranial volume (ICV), age, gender, BMI, previous MI, diabetes, hypertension, smoking, hypercholesterolaemia, PVD and stroke. Results: Amongst 694 subjects, diastolic and mean BP decreased and hence BP pulsatility increased significantly between ages 70 and 73 years. Lower diastolic BP and higher BP pulsatility were associated with higher ICA PI (standardized β, age 70= -0.24, age 73= -0.19, both p<0.001; age 70 β=0.18, p<0.001, age 73 β=0.10, p=0.008 respectively). WML volume was weakly associated with BP at age 70 (diastolic β=0.08, systolic β=0.08, mean β=0.09, all p<0.05) but not with BP variability or pulsatility. Similar but weaker associations were seen at age 73. After adjusting for BP, larger WML volume was associated with higher ICA PI (β=0.10, p=0.012), but not any other measures. All associations were the same for WML Fazekas scores. Conclusions: The relatively weak association between BP and WML may be mediated via ICA pulsatility which is largely driven by falling diastolic BP. This questions the nature of the apparent link between BP and WML." @default.
- W2273670116 created "2016-06-24" @default.
- W2273670116 creator A5004889443 @default.
- W2273670116 creator A5049892384 @default.
- W2273670116 creator A5075609382 @default.
- W2273670116 creator A5078677480 @default.
- W2273670116 creator A5079216137 @default.
- W2273670116 creator A5080452728 @default.
- W2273670116 creator A5087078152 @default.
- W2273670116 date "2013-02-01" @default.
- W2273670116 modified "2023-09-27" @default.
- W2273670116 title "Abstract WP186: Association Between Blood Pressure, Internal Carotid Artery Flow Parameters And Age-related White Matter Disease" @default.
- W2273670116 doi "https://doi.org/10.1161/str.44.suppl_1.awp186" @default.
- W2273670116 hasPublicationYear "2013" @default.
- W2273670116 type Work @default.
- W2273670116 sameAs 2273670116 @default.
- W2273670116 citedByCount "0" @default.
- W2273670116 crossrefType "journal-article" @default.
- W2273670116 hasAuthorship W2273670116A5004889443 @default.
- W2273670116 hasAuthorship W2273670116A5049892384 @default.
- W2273670116 hasAuthorship W2273670116A5075609382 @default.
- W2273670116 hasAuthorship W2273670116A5078677480 @default.
- W2273670116 hasAuthorship W2273670116A5079216137 @default.
- W2273670116 hasAuthorship W2273670116A5080452728 @default.
- W2273670116 hasAuthorship W2273670116A5087078152 @default.
- W2273670116 hasConcept C126322002 @default.
- W2273670116 hasConcept C126838900 @default.
- W2273670116 hasConcept C143409427 @default.
- W2273670116 hasConcept C146638467 @default.
- W2273670116 hasConcept C164705383 @default.
- W2273670116 hasConcept C2778333808 @default.
- W2273670116 hasConcept C2781064879 @default.
- W2273670116 hasConcept C2987047532 @default.
- W2273670116 hasConcept C57900726 @default.
- W2273670116 hasConcept C71924100 @default.
- W2273670116 hasConcept C84393581 @default.
- W2273670116 hasConceptScore W2273670116C126322002 @default.
- W2273670116 hasConceptScore W2273670116C126838900 @default.
- W2273670116 hasConceptScore W2273670116C143409427 @default.
- W2273670116 hasConceptScore W2273670116C146638467 @default.
- W2273670116 hasConceptScore W2273670116C164705383 @default.
- W2273670116 hasConceptScore W2273670116C2778333808 @default.
- W2273670116 hasConceptScore W2273670116C2781064879 @default.
- W2273670116 hasConceptScore W2273670116C2987047532 @default.
- W2273670116 hasConceptScore W2273670116C57900726 @default.
- W2273670116 hasConceptScore W2273670116C71924100 @default.
- W2273670116 hasConceptScore W2273670116C84393581 @default.
- W2273670116 hasIssue "suppl_1" @default.
- W2273670116 hasLocation W22736701161 @default.
- W2273670116 hasOpenAccess W2273670116 @default.
- W2273670116 hasPrimaryLocation W22736701161 @default.
- W2273670116 hasRelatedWork W1699287155 @default.
- W2273670116 hasRelatedWork W2028507273 @default.
- W2273670116 hasRelatedWork W2040991102 @default.
- W2273670116 hasRelatedWork W2073724070 @default.
- W2273670116 hasRelatedWork W2115415822 @default.
- W2273670116 hasRelatedWork W2125366764 @default.
- W2273670116 hasRelatedWork W2144437121 @default.
- W2273670116 hasRelatedWork W2167849004 @default.
- W2273670116 hasRelatedWork W2364242968 @default.
- W2273670116 hasRelatedWork W2375731105 @default.
- W2273670116 hasRelatedWork W2379991395 @default.
- W2273670116 hasRelatedWork W2397520290 @default.
- W2273670116 hasRelatedWork W2465965333 @default.
- W2273670116 hasRelatedWork W2745836864 @default.
- W2273670116 hasRelatedWork W2751536821 @default.
- W2273670116 hasRelatedWork W2756577221 @default.
- W2273670116 hasRelatedWork W2998448000 @default.
- W2273670116 hasRelatedWork W3046781613 @default.
- W2273670116 hasRelatedWork W3096349987 @default.
- W2273670116 hasRelatedWork W3198170758 @default.
- W2273670116 hasVolume "44" @default.
- W2273670116 isParatext "false" @default.
- W2273670116 isRetracted "false" @default.
- W2273670116 magId "2273670116" @default.
- W2273670116 workType "article" @default.