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• W2273792856 abstract "In the last years nanotechnology is strongly influencing the progresses of medicine, in particular against cancer, both for diagnostic and therapeutic purposes. Nanostructures can be planned with properties useful for a specific application. However, the same nanostructure can be synthesized also for more diagnostic techniques. In addiction, one can also plan these nanostructures for what is called multiplexing, namely the presence in the same diagnostic signal of information related to many analytes at the same time. The nanostructures can be synthesized for obtaining targeting, which increases the ability of discriminating different type of tumour associated antigens or, in the case of therapeutic purposes, for the ability of being directed to a specific site.In the present thesis, nanostructures have been synthesized for their applications in particular with two techniques like surface enhanced Raman spectroscopy (SERS) and magnetic resonance imaging (MRI), which are complementary techniques for imaging. The nanostructures have been functionalized also with antibodies for targeting antigens.SERS exploits the huge enhancement of electromagnetic fields of plamonic nanostructures. It is shown that this technique can be used for quantitative measurements of clinically interesting anticancer drugs, with a linear range response in the order of nanomole per millimetre square of SERS active area, which is appropriate also for clinical purposes. It is also demonstrated how molecules with a poor Raman cross section could be revealed with the help of a protocol, called Reactive-SERS, which considers a simple photoactivated reaction.Nanoparticles are obtained with laser ablation and they are found easy to functionalize due to their unique naked surface. It is shown that their properties are useful in laser desorption ionization mass spectrometry. Used as a matrix, they are compared with chemically produced particles and with a widely used organic matrix and they always show the lowest background especially in the low mass region under 500 Da, which is important for the identification of small molecules.Multiplexing analysis are carried out with gold nanoparticles (AuNP) functionalized with different dyes, as SERS reporters, associated to different antibodies. The library of optimized thiolated reporters is increased and makes possible to investigate more complex biological samples. This application is also translated to the cultural heritage research field for the characterization of paint stratigraphic samples.Multimodal contrast agents are developed, coupling the SERS activity, typical of dye functionalized gold nanoparticles, with magnetic sensitive moieties, like iron atoms in alloy nanoparticles or with Gd3+ ions linked to gold nanoparticles. A new polymer, called SuperDOTA, is synthetized for achieving high Gd3+ loadings on the surface of nanoparticles. Preliminary results show that AuNPs, functionalized with both a SERS reporter dye and SuperDOTA-Gd, have useful properties for in vivo MRI tumour analysis and ex-vivo SERS imaging." @default.
• W2273792856 created "2016-06-24" @default.
• W2273792856 creator A5065831128 @default.
• W2273792856 date "2015-02-02" @default.
• W2273792856 modified "2023-09-27" @default.
• W2273792856 title "Plasmonic and Magnetic Nanostructures for Multiplexing Detection and Multiple Imaging Techniques in Bionanomed" @default.
• W2273792856 hasPublicationYear "2015" @default.
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