FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2273835192> ?p ?o ?g. }

• W2273835192 endingPage "45" @default.
• W2273835192 startingPage "835" @default.
• W2273835192 abstract "The clinical features of 68 Japanese patients (53 men and 15 women; mean age 44 years) with primary pulmonary alveolar proteinosis were reviewed. Pulmonary alveolar proteinosis was diagnosed from histologic findings after open lung biopsy (n = 7) or transbronchial lung biopsy (n = 61). Major symptoms were a dry cough (24.2%) and dyspnea or shortness of breath on exertion (51.5%), but one third of the patients were asymptomatic. Crackles were audible in 30% of the patients, but clubbing (6%) and cyanosis (4%) were rare. Ten patients had been occupationally exposed to dust. Slightly less than half (46%) of the patients first presented with symptoms, and the remainder (54%) first presented with abnormal pulmonary infiltrates seen on chest roentgenograms taken during general health examinations. Many patients had abnormally high levels of LDH and CEA in serum (62% and 63%, respectively). Restrictive pulmonary dysfunction (%VC < 80%) was seen in 31% of the patients, an abnormally low DLco (%DLco < 70%) was seen in 62%,m and hypoxemia (PaO2 < 80 mmHg) was seen in 67%. Arterial blood gas tension was closely correlated with the severity of disease in these patients. Chest roentgenograms usually showed bilateral symmetric alveolar infiltrates, mainly distributed from hilar areas toward the pleura, but on CT scans many of the shadows were mixed with alveolar and interstitial infiltrates of various extent along the pulmonary arteries and bronchi. There was no apparent relation between chest roentgenographic findings and chest CT findings in these patients. Neither the extension nor other characteristics of shadows in the chest roentgenograms and chest CT scans were closely related to symptoms, laboratory data, or pulmonary function in these patients. Symptoms were alleviated and chest roentgenographic findings improved in 82% of the 51 patients who underwent therapeutic bronchoalveolar lavage, and in 94% of the 17 patients who did not undergo that procedure. In patients who underwent therapeutic bronchoalveolar lavage and also in those who recovered spontaneously, both diffusing capacity and blood gas values improved significantly. When compared to the patients who did not undergo therapeutic bronchoalveolar lavage, significantly more of those who did undergo that procedure has initial PaO2 values below 60 mmHg, and fewer of them had values greater than 80 mmHg. Thus, a PaO2 below 60 mmHg may be an indication for therapeutic bronchoalveolar lavage in patients with this disease. During the follow-up period (mean 5 years, range 2 months to 23 years), four patients had pneumothorax and none died of pulmonary alveolar proteinosis." @default.
• W2273835192 created "2016-06-24" @default.
• W2273835192 creator A5003073212 @default.
• W2273835192 creator A5004776997 @default.
• W2273835192 creator A5024316557 @default.
• W2273835192 creator A5030889131 @default.
• W2273835192 creator A5059621094 @default.
• W2273835192 date "1995-08-01" @default.
• W2273835192 modified "2023-09-27" @default.
• W2273835192 title "[Primary pulmonary alveolar proteinosis--clinical observation of 68 patients in Japan]." @default.
• W2273835192 cites W1953841807 @default.
• W2273835192 cites W1966116350 @default.
• W2273835192 cites W1988240459 @default.
• W2273835192 cites W2006280550 @default.
• W2273835192 cites W2052566857 @default.
• W2273835192 cites W2054924873 @default.
• W2273835192 cites W2069794822 @default.
• W2273835192 cites W2073088240 @default.
• W2273835192 cites W2082930264 @default.
• W2273835192 cites W2085232829 @default.
• W2273835192 cites W2086644173 @default.
• W2273835192 cites W2177427147 @default.
• W2273835192 cites W2411910220 @default.
• W2273835192 cites W2989337141 @default.
• W2273835192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7474563" @default.
• W2273835192 hasPublicationYear "1995" @default.
• W2273835192 type Work @default.
• W2273835192 sameAs 2273835192 @default.
• W2273835192 citedByCount "18" @default.
• W2273835192 countsByYear W22738351922013 @default.
• W2273835192 countsByYear W22738351922014 @default.
• W2273835192 countsByYear W22738351922017 @default.
• W2273835192 countsByYear W22738351922019 @default.
• W2273835192 crossrefType "journal-article" @default.
• W2273835192 hasAuthorship W2273835192A5003073212 @default.
• W2273835192 hasAuthorship W2273835192A5004776997 @default.
• W2273835192 hasAuthorship W2273835192A5024316557 @default.
• W2273835192 hasAuthorship W2273835192A5030889131 @default.
• W2273835192 hasAuthorship W2273835192A5059621094 @default.
• W2273835192 hasConcept C126322002 @default.
• W2273835192 hasConcept C126838900 @default.
• W2273835192 hasConcept C16020263 @default.
• W2273835192 hasConcept C165637977 @default.
• W2273835192 hasConcept C2776779939 @default.
• W2273835192 hasConcept C2777714996 @default.
• W2273835192 hasConcept C2777910003 @default.
• W2273835192 hasConcept C2778972612 @default.
• W2273835192 hasConcept C2779563453 @default.
• W2273835192 hasConcept C2780908675 @default.
• W2273835192 hasConcept C2910066949 @default.
• W2273835192 hasConcept C3018587741 @default.
• W2273835192 hasConcept C71924100 @default.
• W2273835192 hasConceptScore W2273835192C126322002 @default.
• W2273835192 hasConceptScore W2273835192C126838900 @default.
• W2273835192 hasConceptScore W2273835192C16020263 @default.
• W2273835192 hasConceptScore W2273835192C165637977 @default.
• W2273835192 hasConceptScore W2273835192C2776779939 @default.
• W2273835192 hasConceptScore W2273835192C2777714996 @default.
• W2273835192 hasConceptScore W2273835192C2777910003 @default.
• W2273835192 hasConceptScore W2273835192C2778972612 @default.
• W2273835192 hasConceptScore W2273835192C2779563453 @default.
• W2273835192 hasConceptScore W2273835192C2780908675 @default.
• W2273835192 hasConceptScore W2273835192C2910066949 @default.
• W2273835192 hasConceptScore W2273835192C3018587741 @default.
• W2273835192 hasConceptScore W2273835192C71924100 @default.
• W2273835192 hasIssue "8" @default.
• W2273835192 hasLocation W22738351921 @default.
• W2273835192 hasOpenAccess W2273835192 @default.
• W2273835192 hasPrimaryLocation W22738351921 @default.
• W2273835192 hasRelatedWork W1577398631 @default.
• W2273835192 hasRelatedWork W2038444311 @default.
• W2273835192 hasRelatedWork W2117261268 @default.
• W2273835192 hasRelatedWork W2230299729 @default.
• W2273835192 hasRelatedWork W2273835192 @default.
• W2273835192 hasRelatedWork W2402282464 @default.
• W2273835192 hasRelatedWork W2462976631 @default.
• W2273835192 hasRelatedWork W27509626 @default.
• W2273835192 hasRelatedWork W2989605641 @default.
• W2273835192 hasRelatedWork W3093503105 @default.
• W2273835192 hasVolume "33" @default.
• W2273835192 isParatext "false" @default.
• W2273835192 isRetracted "false" @default.
• W2273835192 magId "2273835192" @default.
• W2273835192 workType "article" @default.