FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W227387200> ?p ?o ?g. }

• W227387200 endingPage "700" @default.
• W227387200 startingPage "693" @default.
• W227387200 abstract "The purpose of this study was to analyse the expression of matrix metalloproteinase-2 (MMP-2) and its extracellular matrix metalloproteinase inducer (EMMPRIN) in non-small cell lung cancer (NSCLC), and to evaluate their significance to predict tumour behaviour. The study consists of 212 patients treated by the resection of the tumour. Tumour samples were stained immunohistochemically, and the expression of MMP-2 and EMMPRIN was evaluated both in tumour cells and in peritumoural stromal tissue. The results were compared with clinicopathological factors and survival of the patients. High expression of MMP-2 in tumour cells was found in 83 out of 191 cases (44%). Adenocarcinomas showed more often high expression of MMP-2 as compared with squamous cell or large cell carcinomas (p=0.001). High cancer cell associated MMP-2 expression was associated with increased tumour recurrence (p=0.001). Tumour stroma showed positive staining in 162 (98%) cases and was considered highly stained in 120 (72%) cases. The high stromal MMP-2 expression was noticed more often among large cell carcinomas as compared with other histological types (p=0.007). High cancer cell associated EMMPRIN expression was found in 115 (61%) cases and was associated only with high MMP-2 expression in tumour cells (p=0.006). In overall survival (OS) and disease free survival (DFS) analyses, type of tumour (p=0.001 and p=0.0004), advanced stage (p=0.001 and p=0.013) and high MMP-2 expression in tumour cells (p=0.018 and p=0.001) were associated with poor survival. Also, high stromal MMP-2 expression was related to poor outcome in both OS and DFS analyses (p=0.010 and 0.045, respectively). In multivariate analysis, stromal MMP-2 expression retained its prognostic value to predict OS and DFS (p=0.028 and p=0.039, respectively), together with tumour type and stage (p=0.017, p=0.001 and p=0.021, p=0.008, respectively). The present study shows the significant prognostic value of MMP-2 in NSCLC suggesting that the use of MMP-2 is valuable in determining the patients with more aggressive disease." @default.
• W227387200 created "2016-06-24" @default.
• W227387200 creator A5019439765 @default.
• W227387200 creator A5052251778 @default.
• W227387200 creator A5066441042 @default.
• W227387200 creator A5084843891 @default.
• W227387200 creator A5088466045 @default.
• W227387200 date "2008-06-01" @default.
• W227387200 modified "2023-10-17" @default.
• W227387200 title "Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer." @default.
• W227387200 cites W1264489 @default.
• W227387200 cites W148105776 @default.
• W227387200 cites W17855875 @default.
• W227387200 cites W1972480656 @default.
• W227387200 cites W1977798072 @default.
• W227387200 cites W1982250680 @default.
• W227387200 cites W1982940590 @default.
• W227387200 cites W1989900054 @default.
• W227387200 cites W1991622808 @default.
• W227387200 cites W1994059078 @default.
• W227387200 cites W1996937427 @default.
• W227387200 cites W2003500892 @default.
• W227387200 cites W2004034027 @default.
• W227387200 cites W2010382703 @default.
• W227387200 cites W2013946320 @default.
• W227387200 cites W2017016115 @default.
• W227387200 cites W2026169826 @default.
• W227387200 cites W2027857471 @default.
• W227387200 cites W2028413004 @default.
• W227387200 cites W2028721376 @default.
• W227387200 cites W2029368519 @default.
• W227387200 cites W2030776545 @default.
• W227387200 cites W2035420579 @default.
• W227387200 cites W2037812980 @default.
• W227387200 cites W2039757013 @default.
• W227387200 cites W2041586000 @default.
• W227387200 cites W2043670884 @default.
• W227387200 cites W2045229611 @default.
• W227387200 cites W2050019914 @default.
• W227387200 cites W2062674015 @default.
• W227387200 cites W2073392864 @default.
• W227387200 cites W2086578936 @default.
• W227387200 cites W2087361393 @default.
• W227387200 cites W2105657168 @default.
• W227387200 cites W2107566688 @default.
• W227387200 cites W2123578869 @default.
• W227387200 cites W2125126707 @default.
• W227387200 cites W2138752972 @default.
• W227387200 cites W2144548546 @default.
• W227387200 cites W2148793382 @default.
• W227387200 cites W2149560261 @default.
• W227387200 cites W2151951159 @default.
• W227387200 cites W2153566920 @default.
• W227387200 cites W2154401382 @default.
• W227387200 cites W2168935753 @default.
• W227387200 cites W2170219548 @default.
• W227387200 cites W259875475 @default.
• W227387200 doi "https://doi.org/10.14670/hh-23.693" @default.
• W227387200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18366007" @default.
• W227387200 hasPublicationYear "2008" @default.
• W227387200 type Work @default.
• W227387200 sameAs 227387200 @default.
• W227387200 citedByCount "26" @default.
• W227387200 countsByYear W2273872002012 @default.
• W227387200 countsByYear W2273872002014 @default.
• W227387200 countsByYear W2273872002015 @default.
• W227387200 countsByYear W2273872002016 @default.
• W227387200 countsByYear W2273872002017 @default.
• W227387200 countsByYear W2273872002018 @default.
• W227387200 countsByYear W2273872002020 @default.
• W227387200 countsByYear W2273872002021 @default.
• W227387200 countsByYear W2273872002022 @default.
• W227387200 countsByYear W2273872002023 @default.
• W227387200 crossrefType "journal-article" @default.
• W227387200 hasAuthorship W227387200A5019439765 @default.
• W227387200 hasAuthorship W227387200A5052251778 @default.
• W227387200 hasAuthorship W227387200A5066441042 @default.
• W227387200 hasAuthorship W227387200A5084843891 @default.
• W227387200 hasAuthorship W227387200A5088466045 @default.
• W227387200 hasConcept C109523444 @default.
• W227387200 hasConcept C121608353 @default.
• W227387200 hasConcept C126322002 @default.
• W227387200 hasConcept C142724271 @default.
• W227387200 hasConcept C146357865 @default.
• W227387200 hasConcept C1491633281 @default.
• W227387200 hasConcept C151730666 @default.
• W227387200 hasConcept C16930146 @default.
• W227387200 hasConcept C189165786 @default.
• W227387200 hasConcept C204232928 @default.
• W227387200 hasConcept C2776256026 @default.
• W227387200 hasConcept C502942594 @default.
• W227387200 hasConcept C54355233 @default.
• W227387200 hasConcept C55728118 @default.
• W227387200 hasConcept C71924100 @default.
• W227387200 hasConcept C86803240 @default.
• W227387200 hasConcept C95444343 @default.
• W227387200 hasConcept C96232424 @default.
• W227387200 hasConceptScore W227387200C109523444 @default.

• next