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- W2273909257 abstract "The human Mixed Lineage Leukaemia-5 (MLL5) gene is frequently deleted in myeloid malignancies. Emerging evidence suggest that MLL5 has important functions in adult hematopoiesis and chromatin regulatory network, and participates in regulating the cell cycle machinery. To further investigate its cellular regulatory functions, we studied the expression and post-translational modification of MLL5 throughout the cell cycle. Our results demonstrated that MLL5 is regulated by cell cycle-dependent phosphorylation, and reduced phosphorylation modification of MLL5 is associated with the inhibition of cell cycle progression. Our data provides a molecular foundation for further investigation on the mechanisms of cell cycle transition or epigenetic regulatory role of MLL5 with the phosphorylation signalling network." @default.
- W2273909257 created "2016-06-24" @default.
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- W2273909257 date "2010-04-01" @default.
- W2273909257 modified "2023-10-16" @default.
- W2273909257 title "PHOSPHORYLATION REGULATION OF MIXED LINEAGE LEUKEMIA 5" @default.
- W2273909257 doi "https://doi.org/10.1096/fasebj.24.1_supplement.lb152" @default.
- W2273909257 hasPublicationYear "2010" @default.
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