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- W22739145 abstract "Pharmacokinetics of oxytetracycline (OTC) was studied inswampmg/kgbuffalo heifers and cows after a single injection ofOTC hydrochloride intravenously and OTC long acting20(LA)formulation (Terramycin/LA, Pfizer) intramuscularly using a crossoverstudy. The concentration of OTC in serum samples was measuredby a bioassay technique using Bacillus cereus (ATCC 11778)as the test organism.The disposition curve for oxytetracycline activities afterintravenous administration was best described by a two-compartmentopen model. The serum concentrations at time zero, co'p, forbuffalo cows and buffalo heifers were 61 . 37+19 . 62 mcg/ml and 33 . 09+9 . 93 mcg/ml respectively . The elimination half-lives forbuffalo cows (10.13+2 . 72 h) and heifers ( 8.72+2.14 h) after intravenousinjection of the drug were not significantly different( P)0.05). The apparent volume o f distribution was significantlyhigher in buffalo cows ( 2.84+0 . 46 L/kg) than in heifers ( 2.0+0.42L/kg ) but the total body clearance did not differ significantly(P>0 . 05) .Following a single intramuscular injection of OTC-LA formulationonly one rate constant of absorption was noted in buffalocows (ka1-0. 05 h) but two rate constants of absorption were notedfor heifers - a fast rate ( ka1-3 . 62 h) and a slow rate ( ka2 -0. 04h). The peak serum concentration of OTC for buffalo cows was4 . 56+1 . 48 mcg/ml at 4.67+1.91 hours and for buffalo heifers was4.40+ 0.57 mcg/ml at 1.67+0.26 hours.The bioavailability of OTCwas 64 and 24 per cent for buffalo cows and heifers respectively .Plasma concentrations above 0.5 mcg/ml were maintained for approximately50-60 hours . The minimum inhibition concentration (MIC)for eleven isolates from diseased buffaloes ranged from 0 . 25 to4.0 mcg/ml .For the swamp buffalo OTC-LA is recommended at a dosing rateof 20 mg/kg injected intramuscularly at 48-hour dosage intervalsfor highly susceptible organisms (MIC<1 mcg/m1 ) . However itis preferable to use the conventional OTC formulation intramuscularlyfor less susceptible organisms (MIC>2 mcg/ml ) ." @default.
- W22739145 created "2016-06-24" @default.
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- W22739145 date "1984-07-01" @default.
- W22739145 modified "2023-09-27" @default.
- W22739145 title "Pharmacokinetics Of Oxytetracycline In The Swamp Buffalo (Bubalus Bubalis)" @default.
- W22739145 hasPublicationYear "1984" @default.
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