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• W2273993443 abstract "484 Background: Pancreatic metastases from renal cell carcinoma (PmRCC) are uncommon and their prognostic value in the era of targeted terapies (TTs) is not well defined. We evaluated the outcome of a cohort of PmRCC patients (pts) who were treated with either surgery and TTs. Methods: PmRCC pts treated between 1993 and 2014 were identified from the databases of 10 European centers. Clinical records were retrospectively reviewed and pts characteristics, including demographics and clinical outcome, were analyzed. Kaplan-Meier methods and log-rank test were used to evaluate progression-free survival (PFS) and overall survival (OS). Cox’s proportional hazard models were used for OS analysis. Results: A total of 232pts were evaluated. Median age was 61 years, sex ratio M/F was 147/85, and PmRCC were synchronous in 69 pts (30%). Pts treated with pancreatic surgery (including radiosurgery) were 67 (29%), while patients receiving systemic treatment were 210 (91%). Pts with only PmRCC were 23 (11%), whereas in the other 201 cases: lung (25%), lymphnodes (16%), and liver (13%) were the most common metastatic sites. The majority of pts (94%) received nephrectomy (Nx). Median time from Nx to PmRCC occurrence was 92 months (IQR 50-143). First-line TTs included: sunitinib (42%), sorafenib (12%), pazopanib (9%), interferon+bevacizumab (8%), and temsirolimus (1%), 30% of pts received cytokines and 65% of pts received subsequent lines of TTs. Best response to first-line treatment were complete response (5%), partial response (41%), and stable disease (36%) with a disease control rate (DCR) of 82% and a median PFS of 12 months (IQR 9-13). Median OS (calculated from the time of PmRCC occurrence to death) was 73 months (IQR 61-90) with a 5-yr OS of 59%. Median OS for pts treated with surgical resection was 114 months (IQR 90-204) with a 5-year OS of 81%. At univariate analysis only Motzer/Heng prognostic score were significantly associated with OS (p=0.006). Conclusions: PmRCC are associated with long-term survival, usually occur many years after Nx and seem to lead to a less aggressive disease. Surgery should be considered in oligometastatic disease as it can be associated with prolonged survival. TTs are active in these pts and achieve high DCR." @default.
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• W2273993443 date "2015-03-01" @default.
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• W2273993443 title "Prognosis and outcome of patients with pancreatic metastases from renal cell carcinoma: When the site matters." @default.
• W2273993443 doi "https://doi.org/10.1200/jco.2015.33.7_suppl.484" @default.
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