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• W2274003852 abstract "During stem cell divisions, mitotic microtubules do more than just segregate the chromosomes. They also determine whether a cell divides virtually symmetrically or asymmetrically by establishing spindle orientation and the plane of cell division. This can be decisive for the fate of the stem cell progeny. Spindle defects have been linked to neurodevelopmental disorders, yet the role of spindle orientation for mammalian neurogenesis has remained controversial. Here we explore recent advances in understanding how the microtubule cytoskeleton influences mammalian neural stem cell division. Our focus is primarily on the role of spindle microtubules in the development of the cerebral cortex. We also highlight unique characteristics in the architecture and dynamics of cortical stem cells that are tightly linked to their mode of division. These features contribute to setting these cells apart as mitotic rule breakers, control how asymmetric a division is, and, we argue, are sufficient to determine the fate of the neural stem cell progeny in mammals." @default.
• W2274003852 created "2016-06-24" @default.
• W2274003852 creator A5027036729 @default.
• W2274003852 creator A5041088627 @default.
• W2274003852 date "2015-12-01" @default.
• W2274003852 modified "2023-10-16" @default.
• W2274003852 title "Novel insights into mammalian embryonic neural stem cell division: focus on microtubules" @default.
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• W2274003852 doi "https://doi.org/10.1091/mbc.e15-03-0152" @default.
• W2274003852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4666126" @default.
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• W2274003852 hasPublicationYear "2015" @default.
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