Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274101275> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2274101275 endingPage "225" @default.
- W2274101275 startingPage "220" @default.
- W2274101275 abstract "Background and objective It has been proven that suppressor of cytokine signaling 3 (SOCS3) contributes to inhibition of cell overgrowth, induction of apoptosis and stabilization. In the present study, we addressed the SOCS3 expression in non-small cell lung cancer (NSCLC) and explored the relationship between SOCS3 expression and lymph node metastases as well as clinicopathological characteristics in lung cancer patients. Methods Western blotting analysis was used to examine the expression of SOCS3 in 30 NSCLCs and non-tumor tissues. The methylated status of SOCS3 gene was determined by methylation-specific PCR (MSP) assay in the same 30 samples. Immunohistochemical staining was applied to determine SOCS3 expression in 90 NSCLC sections and the correlation of SOCS3 expression with lymph node metastases and clinicopathological characteristics was also analyzed. Results SOCS3 expression was much lower in 30 NSCLCs than tnat in non-tumorous counterparts of the same case (optical density were 26.3±12.3 and 78.4±14.5 respectively, P =0.000) by western blotting analysis. MSP showed that the methylated rate of SOCS3 genewas (20/30) 66.7% in NSCLCs, and (4/30) 13.3% in non-tumors, and SOCS3 expression was negatively correlated with methylation (r =-0.454?P =0.012). Furthermore, SOCS3 expression was observed in non-tumorous epithelial cells byimmunohistochemiscal analysis, and the positive rate of SOCS3 expression in 90 NSCLC samples was (41/90) 45.6%. SOCS3 expression rate was lower in NSCLCs with lymph node metastases (35.4%) compared with non-metastatic NSCLCs(57.1%, P =0.039), and in NSCLCs of stage III (36.4%) than in stage I+II (60.0%, P =0.028). SOCS3 expression was notcorrelated with histological type or differentiation (P >0.05). Conclusion The results of this study suggest that Downregulationof SOCS3 expression in NSCLC associated with methylation might be correlated with lymph node metastases as well as clinicopathological stage of NSCLCs." @default.
- W2274101275 created "2016-06-24" @default.
- W2274101275 creator A5000546219 @default.
- W2274101275 creator A5013121236 @default.
- W2274101275 creator A5023811312 @default.
- W2274101275 creator A5029226478 @default.
- W2274101275 creator A5079611901 @default.
- W2274101275 date "2008-04-20" @default.
- W2274101275 modified "2023-09-22" @default.
- W2274101275 title "[Down-regulation of SOCS3 expression by methylation correlates with lymph node metastases of NSCLCs.]." @default.
- W2274101275 doi "https://doi.org/10.3779/j.issn.1009-3419.2008.02.008" @default.
- W2274101275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20731905" @default.
- W2274101275 hasPublicationYear "2008" @default.
- W2274101275 type Work @default.
- W2274101275 sameAs 2274101275 @default.
- W2274101275 citedByCount "0" @default.
- W2274101275 crossrefType "journal-article" @default.
- W2274101275 hasAuthorship W2274101275A5000546219 @default.
- W2274101275 hasAuthorship W2274101275A5013121236 @default.
- W2274101275 hasAuthorship W2274101275A5023811312 @default.
- W2274101275 hasAuthorship W2274101275A5029226478 @default.
- W2274101275 hasAuthorship W2274101275A5079611901 @default.
- W2274101275 hasConcept C104317684 @default.
- W2274101275 hasConcept C121608353 @default.
- W2274101275 hasConcept C126042315 @default.
- W2274101275 hasConcept C126322002 @default.
- W2274101275 hasConcept C142724271 @default.
- W2274101275 hasConcept C150194340 @default.
- W2274101275 hasConcept C179185449 @default.
- W2274101275 hasConcept C190727270 @default.
- W2274101275 hasConcept C204232928 @default.
- W2274101275 hasConcept C2776256026 @default.
- W2274101275 hasConcept C2777546739 @default.
- W2274101275 hasConcept C2780849966 @default.
- W2274101275 hasConcept C33288867 @default.
- W2274101275 hasConcept C502942594 @default.
- W2274101275 hasConcept C55493867 @default.
- W2274101275 hasConcept C71924100 @default.
- W2274101275 hasConcept C86803240 @default.
- W2274101275 hasConceptScore W2274101275C104317684 @default.
- W2274101275 hasConceptScore W2274101275C121608353 @default.
- W2274101275 hasConceptScore W2274101275C126042315 @default.
- W2274101275 hasConceptScore W2274101275C126322002 @default.
- W2274101275 hasConceptScore W2274101275C142724271 @default.
- W2274101275 hasConceptScore W2274101275C150194340 @default.
- W2274101275 hasConceptScore W2274101275C179185449 @default.
- W2274101275 hasConceptScore W2274101275C190727270 @default.
- W2274101275 hasConceptScore W2274101275C204232928 @default.
- W2274101275 hasConceptScore W2274101275C2776256026 @default.
- W2274101275 hasConceptScore W2274101275C2777546739 @default.
- W2274101275 hasConceptScore W2274101275C2780849966 @default.
- W2274101275 hasConceptScore W2274101275C33288867 @default.
- W2274101275 hasConceptScore W2274101275C502942594 @default.
- W2274101275 hasConceptScore W2274101275C55493867 @default.
- W2274101275 hasConceptScore W2274101275C71924100 @default.
- W2274101275 hasConceptScore W2274101275C86803240 @default.
- W2274101275 hasIssue "2" @default.
- W2274101275 hasLocation W22741012751 @default.
- W2274101275 hasLocation W22741012752 @default.
- W2274101275 hasOpenAccess W2274101275 @default.
- W2274101275 hasPrimaryLocation W22741012751 @default.
- W2274101275 hasRelatedWork W1851152610 @default.
- W2274101275 hasRelatedWork W2347847316 @default.
- W2274101275 hasRelatedWork W2349503315 @default.
- W2274101275 hasRelatedWork W2357515129 @default.
- W2274101275 hasRelatedWork W2357933276 @default.
- W2274101275 hasRelatedWork W2360272507 @default.
- W2274101275 hasRelatedWork W2360303251 @default.
- W2274101275 hasRelatedWork W2362979587 @default.
- W2274101275 hasRelatedWork W2366056025 @default.
- W2274101275 hasRelatedWork W2366682490 @default.
- W2274101275 hasRelatedWork W2370640439 @default.
- W2274101275 hasRelatedWork W2372279583 @default.
- W2274101275 hasRelatedWork W2374999671 @default.
- W2274101275 hasRelatedWork W2385613647 @default.
- W2274101275 hasRelatedWork W2388415914 @default.
- W2274101275 hasRelatedWork W2388424652 @default.
- W2274101275 hasRelatedWork W2389531896 @default.
- W2274101275 hasRelatedWork W2392961903 @default.
- W2274101275 hasRelatedWork W2393098587 @default.
- W2274101275 hasRelatedWork W3030454459 @default.
- W2274101275 hasVolume "11" @default.
- W2274101275 isParatext "false" @default.
- W2274101275 isRetracted "false" @default.
- W2274101275 magId "2274101275" @default.
- W2274101275 workType "article" @default.