FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274127002> ?p ?o ?g. }

• W2274127002 endingPage "15505" @default.
• W2274127002 startingPage "15505" @default.
• W2274127002 abstract "15505 Introduction: Quality of surgical resection is an important prognostic factor for gastrointestinal stromal tumor (GIST) and large GIST has a worse prognosis because resection is often marginal. We conducted a registered multicentric phase II trial to evaluate the efficacy of imatinib when administered preoperatively. Material and Methods: The trial was opened in 7 centers and forty-four patients were planned to be included. An interim analysis was done after 16 patients. Patients were considered eligible if they had a kit (CD-117) positive gist with a risk of an incomplete resection of 20 percent or higher (tumor attached to 3 or more adjacent organs or larger than 10 cm) or if surgery with high morbidity was planned. Imatinib was started at 400 mg po id and increased to 600 mg po id if response to treatment was not sufficient. Response to treatment was measured according to recist criteria at 6 and 12 weeks, and then every 8 weeks until best response had been reached for a maximum of 52 weeks. Surgery was planned to be performed between 6 and 12 months of neoadjuvant treatment. Results: Between 2005 and 2007, 16 patients were enrolled. Gist originated from the stomach in 9 patients, esophagus in 1 and small bowel in 6. Twelve patients completed the study. Six patients underwent r0 surgery after partial response (pr) with 400 mg for 12 months. Four had an initial progressive disease (pd) and then received 600 mg (one partial response (pr), 2 stable disease (sd) and one progression). One pr patient had surgery at 8 weeks for gastrointestinal bleeding and one cr patient refused surgery. Four patients are still under treatment and have pr. At surgery (n=11), residual tumor cells were found in all patients. An r0 resection was possible in 9 patients and the surgical strategy was changed in 8 patients. Conclusion: Imatinib 400 mg is efficient as neoadjuvant treatment for patients with large gist but cr is rare (1/12), even when 600 mg is used. In this series, neoadjuvant treatment with imatinib led to a more conservative surgical resection in 72% of patients and to an r0 resection in 81% of them. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration AstraZeneca Oncology, Novartis, Roche, sanofi-aventis AstraZeneca Oncology, Novartis, Roche, sanofi-aventis" @default.
• W2274127002 created "2016-06-24" @default.
• W2274127002 creator A5010801722 @default.
• W2274127002 creator A5044448931 @default.
• W2274127002 creator A5046412807 @default.
• W2274127002 creator A5064806994 @default.
• W2274127002 creator A5075266574 @default.
• W2274127002 date "2008-05-20" @default.
• W2274127002 modified "2023-09-25" @default.
• W2274127002 title "Preoperative administration of imatinib in patients with large gastrointestinal stromal tumors can change surgical strategy and improve the quality of resection in most patients: Clinical results of gap study" @default.
• W2274127002 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.15505" @default.
• W2274127002 hasPublicationYear "2008" @default.
• W2274127002 type Work @default.
• W2274127002 sameAs 2274127002 @default.
• W2274127002 citedByCount "0" @default.
• W2274127002 crossrefType "journal-article" @default.
• W2274127002 hasAuthorship W2274127002A5010801722 @default.
• W2274127002 hasAuthorship W2274127002A5044448931 @default.
• W2274127002 hasAuthorship W2274127002A5046412807 @default.
• W2274127002 hasAuthorship W2274127002A5064806994 @default.
• W2274127002 hasAuthorship W2274127002A5075266574 @default.
• W2274127002 hasConcept C126322002 @default.
• W2274127002 hasConcept C141071460 @default.
• W2274127002 hasConcept C168563851 @default.
• W2274127002 hasConcept C16930146 @default.
• W2274127002 hasConcept C203092338 @default.
• W2274127002 hasConcept C2775922572 @default.
• W2274127002 hasConcept C2776694085 @default.
• W2274127002 hasConcept C2777007597 @default.
• W2274127002 hasConcept C2777583451 @default.
• W2274127002 hasConcept C2778729363 @default.
• W2274127002 hasConcept C2778822529 @default.
• W2274127002 hasConcept C2779984678 @default.
• W2274127002 hasConcept C3019892230 @default.
• W2274127002 hasConcept C61943457 @default.
• W2274127002 hasConcept C71924100 @default.
• W2274127002 hasConceptScore W2274127002C126322002 @default.
• W2274127002 hasConceptScore W2274127002C141071460 @default.
• W2274127002 hasConceptScore W2274127002C168563851 @default.
• W2274127002 hasConceptScore W2274127002C16930146 @default.
• W2274127002 hasConceptScore W2274127002C203092338 @default.
• W2274127002 hasConceptScore W2274127002C2775922572 @default.
• W2274127002 hasConceptScore W2274127002C2776694085 @default.
• W2274127002 hasConceptScore W2274127002C2777007597 @default.
• W2274127002 hasConceptScore W2274127002C2777583451 @default.
• W2274127002 hasConceptScore W2274127002C2778729363 @default.
• W2274127002 hasConceptScore W2274127002C2778822529 @default.
• W2274127002 hasConceptScore W2274127002C2779984678 @default.
• W2274127002 hasConceptScore W2274127002C3019892230 @default.
• W2274127002 hasConceptScore W2274127002C61943457 @default.
• W2274127002 hasConceptScore W2274127002C71924100 @default.
• W2274127002 hasIssue "15_suppl" @default.
• W2274127002 hasLocation W22741270021 @default.
• W2274127002 hasOpenAccess W2274127002 @default.
• W2274127002 hasPrimaryLocation W22741270021 @default.
• W2274127002 hasRelatedWork W1992841518 @default.
• W2274127002 hasRelatedWork W2000495228 @default.
• W2274127002 hasRelatedWork W2097980522 @default.
• W2274127002 hasRelatedWork W2100902854 @default.
• W2274127002 hasRelatedWork W2132190370 @default.
• W2274127002 hasRelatedWork W2139020082 @default.
• W2274127002 hasRelatedWork W2274127002 @default.
• W2274127002 hasRelatedWork W2411341938 @default.
• W2274127002 hasRelatedWork W2560441664 @default.
• W2274127002 hasRelatedWork W2896338156 @default.
• W2274127002 hasVolume "26" @default.
• W2274127002 isParatext "false" @default.
• W2274127002 isRetracted "false" @default.
• W2274127002 magId "2274127002" @default.
• W2274127002 workType "article" @default.