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• W2274185334 endingPage "275" @default.
• W2274185334 startingPage "265" @default.
• W2274185334 abstract "Ethanol and cocaine are widely abused drugs triggering long-lasting changes in neuronal circuits and synaptic transmission through the regulation of enzyme activity and gene expression. Compelling evidence indicates that the ubiquitin-proteasome system plays a role in the molecular changes induced by addictive substances, impacting on several mechanisms implicated in abuse. The goal of these studies was to evaluate the effects of cocaine or ethanol on proteasome activity in neuroblastoma cells. Moreover, the gene expression of specific subunits was assessed. Chymotrypsin-like activity was measured after 2 h, 24 h, and 48 h exposure to 5 μM cocaine or 40 mM ethanol. Proteasome subunit transcripts were evaluated by qPCR at the same time-points. Treatments modified proteasome function in opposite directions, since cocaine increased and ethanol reduced chymotrypsin-like activity. Interestingly, we observed gene expression alterations induced by these drugs. In the core particle, the β1 and α5 subunits were mainly up-regulated by cocaine, whereas α6 transcripts were mostly decreased. β2 and β5 did not change. Similarly, ethanol exposure generally increased β1 and α5 mRNAs. Moreover, the β2 subunit was significantly up-regulated by ethanol only. The β5 and α6 subunits were not altered. In the regulatory particle, Rpt3 was increased by cocaine exposure, whereas it was reduced by ethanol. No significant Rpn9 alterations were observed. These findings support the notion that addictive substances regulate proteasome function, contributing to the dysregulations related to drug abuse since the availability of adequate subunit amounts is necessary for proper complex assembly and function." @default.
• W2274185334 created "2016-06-24" @default.
• W2274185334 creator A5002549616 @default.
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• W2274185334 creator A5025307452 @default.
• W2274185334 creator A5075565909 @default.
• W2274185334 creator A5078562133 @default.
• W2274185334 date "2016-04-01" @default.
• W2274185334 modified "2023-09-27" @default.
• W2274185334 title "Cocaine and ethanol target 26S proteasome activity and gene expression in neuroblastoma cells" @default.
• W2274185334 cites W117967540 @default.
• W2274185334 cites W1598548078 @default.
• W2274185334 cites W1775287346 @default.
• W2274185334 cites W1966670273 @default.
• W2274185334 cites W1968120534 @default.
• W2274185334 cites W1970161481 @default.
• W2274185334 cites W1971841367 @default.
• W2274185334 cites W1976626715 @default.
• W2274185334 cites W1977266560 @default.
• W2274185334 cites W1977454301 @default.
• W2274185334 cites W1978266818 @default.
• W2274185334 cites W1980060298 @default.
• W2274185334 cites W1982143936 @default.
• W2274185334 cites W1983404135 @default.
• W2274185334 cites W1989407684 @default.
• W2274185334 cites W1991558827 @default.
• W2274185334 cites W1994761764 @default.
• W2274185334 cites W1994795394 @default.
• W2274185334 cites W2002057405 @default.
• W2274185334 cites W2006107392 @default.
• W2274185334 cites W2006641546 @default.
• W2274185334 cites W2007050986 @default.
• W2274185334 cites W2008492694 @default.
• W2274185334 cites W2011813413 @default.
• W2274185334 cites W2013608375 @default.
• W2274185334 cites W2017228134 @default.
• W2274185334 cites W2027344089 @default.
• W2274185334 cites W2035402655 @default.
• W2274185334 cites W2039503906 @default.
• W2274185334 cites W2046244922 @default.
• W2274185334 cites W2046860176 @default.
• W2274185334 cites W2047050750 @default.
• W2274185334 cites W2049567972 @default.
• W2274185334 cites W2049796382 @default.
• W2274185334 cites W2055145544 @default.
• W2274185334 cites W2057430366 @default.
• W2274185334 cites W2058590072 @default.
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• W2274185334 cites W2065358038 @default.
• W2274185334 cites W2066051957 @default.
• W2274185334 cites W2068847043 @default.
• W2274185334 cites W2069332463 @default.
• W2274185334 cites W2069507909 @default.
• W2274185334 cites W2070651154 @default.
• W2274185334 cites W2078064851 @default.
• W2274185334 cites W2079123938 @default.
• W2274185334 cites W2081554656 @default.
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• W2274185334 cites W2153998371 @default.
• W2274185334 cites W2156245197 @default.
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• W2274185334 doi "https://doi.org/10.1016/j.drugalcdep.2016.02.012" @default.
• W2274185334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26922280" @default.
• W2274185334 hasPublicationYear "2016" @default.
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• W2274185334 hasAuthorship W2274185334A5025307452 @default.
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