FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274212297> ?p ?o ?g. }

• W2274212297 endingPage "470" @default.
• W2274212297 startingPage "463" @default.
• W2274212297 abstract "Hydrogen sulfide (H2S) reportedly acts as a gasotransmitter because it mediates various cellular responses through several ion channels including ATP-sensitive K(+) (KATP) channels and transient receptor potential (TRP) A1 channels. H2S can activate both KATP and TRPA1 channels at a similar concentration range. In a single cell expressing both channels, however, it remains unknown what happens when both channels are simultaneously activated by H2S. In this study, we examined the effects of H2S on RIN14B cells that express both KATP and TRPA1 channels. RIN14B cells showed several intracellular Ca(2+) concentration ([Ca(2+)]i) responses to NaHS (300 µM), an H2S donor, i.e., inhibition of spontaneous Ca(2+) oscillations (37%), inhibition followed by [Ca(2+)]i increase (24%), and a rapid increase in [Ca(2+)]i (25%). KATP channel blockers, glibenclamide or tolbutamide, abolished any inhibitory effects of NaHS and enhanced NaHS-mediated [Ca(2+)]i increases, which were inhibited by extracellular Ca(2+) removal, HC030031 (a TRPA1 antagonist), and disulfide bond-reducing agents. NaHS induced 5-hydroxytryptamine (5-HT) release from RIN14B cells, which was also inhibited by TRPA1 antagonists. These results indicate that H2S has both inhibitory and excitatory effects by opening KATP and TRPA1 channels, respectively, in RIN14B cells, suggesting potential bidirectional modulation of secretory functions." @default.
• W2274212297 created "2016-06-24" @default.
• W2274212297 creator A5007867214 @default.
• W2274212297 creator A5009763181 @default.
• W2274212297 creator A5032629651 @default.
• W2274212297 creator A5064125582 @default.
• W2274212297 creator A5088498456 @default.
• W2274212297 date "2015-10-01" @default.
• W2274212297 modified "2023-10-12" @default.
• W2274212297 title "Bidirectional effects of hydrogen sulfide via ATP-sensitive K+ channels and transient receptor potential A1 channels in RIN14B cells" @default.
• W2274212297 cites W1203377529 @default.
• W2274212297 cites W1554102132 @default.
• W2274212297 cites W1584198387 @default.
• W2274212297 cites W1661770547 @default.
• W2274212297 cites W1817269801 @default.
• W2274212297 cites W1849483132 @default.
• W2274212297 cites W1972603950 @default.
• W2274212297 cites W1974361621 @default.
• W2274212297 cites W1979264967 @default.
• W2274212297 cites W1987738073 @default.
• W2274212297 cites W1989410628 @default.
• W2274212297 cites W2003828608 @default.
• W2274212297 cites W2008071826 @default.
• W2274212297 cites W2009967312 @default.
• W2274212297 cites W2015407072 @default.
• W2274212297 cites W2020833052 @default.
• W2274212297 cites W2020855492 @default.
• W2274212297 cites W2024033984 @default.
• W2274212297 cites W2028606217 @default.
• W2274212297 cites W2032861502 @default.
• W2274212297 cites W2035257142 @default.
• W2274212297 cites W2035495492 @default.
• W2274212297 cites W2046083799 @default.
• W2274212297 cites W2046713672 @default.
• W2274212297 cites W2054734154 @default.
• W2274212297 cites W2056262370 @default.
• W2274212297 cites W2056283223 @default.
• W2274212297 cites W2061896756 @default.
• W2274212297 cites W2062978707 @default.
• W2274212297 cites W2066505423 @default.
• W2274212297 cites W2067469839 @default.
• W2274212297 cites W2076645056 @default.
• W2274212297 cites W2082238995 @default.
• W2274212297 cites W2095581675 @default.
• W2274212297 cites W2102247752 @default.
• W2274212297 cites W2110899027 @default.
• W2274212297 cites W2120229762 @default.
• W2274212297 cites W2142244748 @default.
• W2274212297 cites W2148959338 @default.
• W2274212297 cites W2156291426 @default.
• W2274212297 cites W2164983923 @default.
• W2274212297 cites W2172211138 @default.
• W2274212297 doi "https://doi.org/10.1016/j.ejphar.2015.07.029" @default.
• W2274212297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26172081" @default.
• W2274212297 hasPublicationYear "2015" @default.
• W2274212297 type Work @default.
• W2274212297 sameAs 2274212297 @default.
• W2274212297 citedByCount "11" @default.
• W2274212297 countsByYear W22742122972016 @default.
• W2274212297 countsByYear W22742122972017 @default.
• W2274212297 countsByYear W22742122972018 @default.
• W2274212297 countsByYear W22742122972019 @default.
• W2274212297 countsByYear W22742122972020 @default.
• W2274212297 countsByYear W22742122972021 @default.
• W2274212297 countsByYear W22742122972023 @default.
• W2274212297 crossrefType "journal-article" @default.
• W2274212297 hasAuthorship W2274212297A5007867214 @default.
• W2274212297 hasAuthorship W2274212297A5009763181 @default.
• W2274212297 hasAuthorship W2274212297A5032629651 @default.
• W2274212297 hasAuthorship W2274212297A5064125582 @default.
• W2274212297 hasAuthorship W2274212297A5088498456 @default.
• W2274212297 hasBestOaLocation W22742122972 @default.
• W2274212297 hasConcept C12554922 @default.
• W2274212297 hasConcept C134018914 @default.
• W2274212297 hasConcept C155164980 @default.
• W2274212297 hasConcept C170493617 @default.
• W2274212297 hasConcept C17077164 @default.
• W2274212297 hasConcept C185592680 @default.
• W2274212297 hasConcept C2776885963 @default.
• W2274212297 hasConcept C2779768347 @default.
• W2274212297 hasConcept C28406088 @default.
• W2274212297 hasConcept C50254741 @default.
• W2274212297 hasConcept C55493867 @default.
• W2274212297 hasConcept C555293320 @default.
• W2274212297 hasConcept C79879829 @default.
• W2274212297 hasConcept C83743174 @default.
• W2274212297 hasConcept C86803240 @default.
• W2274212297 hasConcept C95444343 @default.
• W2274212297 hasConcept C98274493 @default.
• W2274212297 hasConceptScore W2274212297C12554922 @default.
• W2274212297 hasConceptScore W2274212297C134018914 @default.
• W2274212297 hasConceptScore W2274212297C155164980 @default.
• W2274212297 hasConceptScore W2274212297C170493617 @default.
• W2274212297 hasConceptScore W2274212297C17077164 @default.
• W2274212297 hasConceptScore W2274212297C185592680 @default.
• W2274212297 hasConceptScore W2274212297C2776885963 @default.
• W2274212297 hasConceptScore W2274212297C2779768347 @default.
• W2274212297 hasConceptScore W2274212297C28406088 @default.

• next