Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274294844> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2274294844 abstract "This study investigated the acute effects of troglitazone (Tro) on glucose and fatty acid (FA) partitioning in skeletal muscle. Exposure of L6 myotubes to Tro for 1h resulted in ∼1.3- and ∼1.6-fold increases in palmitate oxidation and CPT-1 activity, respectively. Tro inhibited basal (∼25%) and insulin-stimulated (∼35%) palmitate uptake but significantly increased basal (∼2.2-fold) and insulin-stimulated (∼2.7-fold) glucose uptake. Inhibition of AMPK prevented the effects of Tro on palmitate oxidation and glucose uptake. Although Tro exerted an insulin sensitizing effect, it reduced basal and insulin-stimulated rates of glycogen synthesis, incorporation of glucose into lipids, and glucose oxidation to values corresponding to ∼30%, ∼60%, and 30% of the controls, respectively. These effects were accompanied by an increase in basal and insulin-stimulated phosphorylation of AktThr308, AktSer473, and GSK3α/β. Tro also powerfully suppressed pyruvate decarboxylation, which was followed by a significant increase in basal (∼3.5-fold) and insulin-stimulated (∼5.5-fold) rates of lactate production. In summary, we provide novel evidence that Tro exerts acute insulin sensitizing effects by increasing FA oxidation, reducing FA uptake, suppressing pyruvate dehydrogenase activity, and shifting glucose metabolism towards lactate production in muscle cells. Funding was provided by NSERC, CIHR, and CDA." @default.
- W2274294844 created "2016-06-24" @default.
- W2274294844 creator A5004600722 @default.
- W2274294844 creator A5044188550 @default.
- W2274294844 creator A5048724319 @default.
- W2274294844 creator A5050718545 @default.
- W2274294844 creator A5065830801 @default.
- W2274294844 creator A5071194143 @default.
- W2274294844 date "2008-03-01" @default.
- W2274294844 modified "2023-09-27" @default.
- W2274294844 title "The acute insulin sensitizing effects of troglitazone are mediated by AMPK activation and inhibition of pyruvate dehyrogenase activity" @default.
- W2274294844 doi "https://doi.org/10.1096/fasebj.22.1_supplement.807.24" @default.
- W2274294844 hasPublicationYear "2008" @default.
- W2274294844 type Work @default.
- W2274294844 sameAs 2274294844 @default.
- W2274294844 citedByCount "0" @default.
- W2274294844 crossrefType "journal-article" @default.
- W2274294844 hasAuthorship W2274294844A5004600722 @default.
- W2274294844 hasAuthorship W2274294844A5044188550 @default.
- W2274294844 hasAuthorship W2274294844A5048724319 @default.
- W2274294844 hasAuthorship W2274294844A5050718545 @default.
- W2274294844 hasAuthorship W2274294844A5065830801 @default.
- W2274294844 hasAuthorship W2274294844A5071194143 @default.
- W2274294844 hasConcept C11960822 @default.
- W2274294844 hasConcept C126322002 @default.
- W2274294844 hasConcept C134018914 @default.
- W2274294844 hasConcept C140137476 @default.
- W2274294844 hasConcept C170493617 @default.
- W2274294844 hasConcept C181199279 @default.
- W2274294844 hasConcept C185592680 @default.
- W2274294844 hasConcept C187345961 @default.
- W2274294844 hasConcept C192118531 @default.
- W2274294844 hasConcept C20904676 @default.
- W2274294844 hasConcept C2777499176 @default.
- W2274294844 hasConcept C2777866211 @default.
- W2274294844 hasConcept C2778024521 @default.
- W2274294844 hasConcept C2778150266 @default.
- W2274294844 hasConcept C2779306644 @default.
- W2274294844 hasConcept C2780124434 @default.
- W2274294844 hasConcept C55493867 @default.
- W2274294844 hasConcept C62231903 @default.
- W2274294844 hasConcept C71924100 @default.
- W2274294844 hasConcept C86803240 @default.
- W2274294844 hasConcept C97029542 @default.
- W2274294844 hasConceptScore W2274294844C11960822 @default.
- W2274294844 hasConceptScore W2274294844C126322002 @default.
- W2274294844 hasConceptScore W2274294844C134018914 @default.
- W2274294844 hasConceptScore W2274294844C140137476 @default.
- W2274294844 hasConceptScore W2274294844C170493617 @default.
- W2274294844 hasConceptScore W2274294844C181199279 @default.
- W2274294844 hasConceptScore W2274294844C185592680 @default.
- W2274294844 hasConceptScore W2274294844C187345961 @default.
- W2274294844 hasConceptScore W2274294844C192118531 @default.
- W2274294844 hasConceptScore W2274294844C20904676 @default.
- W2274294844 hasConceptScore W2274294844C2777499176 @default.
- W2274294844 hasConceptScore W2274294844C2777866211 @default.
- W2274294844 hasConceptScore W2274294844C2778024521 @default.
- W2274294844 hasConceptScore W2274294844C2778150266 @default.
- W2274294844 hasConceptScore W2274294844C2779306644 @default.
- W2274294844 hasConceptScore W2274294844C2780124434 @default.
- W2274294844 hasConceptScore W2274294844C55493867 @default.
- W2274294844 hasConceptScore W2274294844C62231903 @default.
- W2274294844 hasConceptScore W2274294844C71924100 @default.
- W2274294844 hasConceptScore W2274294844C86803240 @default.
- W2274294844 hasConceptScore W2274294844C97029542 @default.
- W2274294844 hasFunder F4320308044 @default.
- W2274294844 hasFunder F4320334506 @default.
- W2274294844 hasFunder F4320334593 @default.
- W2274294844 hasIssue "S1" @default.
- W2274294844 hasLocation W22742948441 @default.
- W2274294844 hasOpenAccess W2274294844 @default.
- W2274294844 hasPrimaryLocation W22742948441 @default.
- W2274294844 hasRelatedWork W1981707303 @default.
- W2274294844 hasRelatedWork W1998638803 @default.
- W2274294844 hasRelatedWork W2012829116 @default.
- W2274294844 hasRelatedWork W2041249629 @default.
- W2274294844 hasRelatedWork W2047134324 @default.
- W2274294844 hasRelatedWork W2101457200 @default.
- W2274294844 hasRelatedWork W2105333927 @default.
- W2274294844 hasRelatedWork W2243166944 @default.
- W2274294844 hasRelatedWork W2414816888 @default.
- W2274294844 hasRelatedWork W4254172584 @default.
- W2274294844 hasVolume "22" @default.
- W2274294844 isParatext "false" @default.
- W2274294844 isRetracted "false" @default.
- W2274294844 magId "2274294844" @default.
- W2274294844 workType "article" @default.