Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274366928> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2274366928 abstract "Toxicological investigations provide key observations for establishing potential impacts of chemicals and other materials in environmental exposures. The specific evaluation of chemical toxicity can be drawn from numerous lines of evidence, including, but, not l imited to: lethality, sub-lethal impacts, toxicokinetics, critical tissue residues, molecular toxicology, reproductive impacts, mutation, carcinogenesis, decreased genetic diversity in populations and decreased species diversity. Despite this richness of potential observations, many predictive toxicological models, such as those included in life cycle impact assessment (LCIA), generally rely on one or a few ecotoxicity measures including median lethal concentrations (LC50) and no observed effects concentrations (NOECs). By excluding all but these composite effects metrics, such models often fail to accurately and/or robustly capture potential adverse outcomes that may negatively affect individual health, biological fitness and/ or population sustainability. Although each has the potential to add value to chemical risk as sessment, the relative importance of the various toxicological observations available for characterizing and assessing environmental impact has not been established. Therefore, we sought to establish the importance of multiple ecotoxicological lines of evidence for assessing environmental impacts. Importance in this context is a subjective valuation based on per ceived utility within an assessment, therefore we developed and administered a survey to query subject matter experts (SMEs) in the fields of toxicology, ecotoxicology and risk as sessment on the importance of a broad array of ecotoxicological measurements. This s coping study focused on SME opinions from Department of Defense scientists and risk as sessors where 61 surveys were distributed and 21 returned and analyzed. Overall, ob servations from chronic exposures and reproductive endpoints were ranked the highest am ong SMEs while lines of evidence from in vivo studies outranked both in vitro and in silico observations." @default.
- W2274366928 created "2016-06-24" @default.
- W2274366928 creator A5001872080 @default.
- W2274366928 creator A5004367115 @default.
- W2274366928 creator A5045705423 @default.
- W2274366928 creator A5080431101 @default.
- W2274366928 date "2015-08-24" @default.
- W2274366928 modified "2023-09-23" @default.
- W2274366928 title "Ranking the Relative Importance of Toxicological Observations Based on Subject Matter Expertise" @default.
- W2274366928 cites W1509866077 @default.
- W2274366928 cites W1964158536 @default.
- W2274366928 cites W2000089305 @default.
- W2274366928 cites W2036694855 @default.
- W2274366928 cites W2048092465 @default.
- W2274366928 cites W2053597171 @default.
- W2274366928 cites W2149604604 @default.
- W2274366928 cites W2156725384 @default.
- W2274366928 cites W2329655658 @default.
- W2274366928 cites W955578938 @default.
- W2274366928 doi "https://doi.org/10.6084/m9.figshare.1517802.v3" @default.
- W2274366928 hasPublicationYear "2015" @default.
- W2274366928 type Work @default.
- W2274366928 sameAs 2274366928 @default.
- W2274366928 citedByCount "0" @default.
- W2274366928 crossrefType "journal-article" @default.
- W2274366928 hasAuthorship W2274366928A5001872080 @default.
- W2274366928 hasAuthorship W2274366928A5004367115 @default.
- W2274366928 hasAuthorship W2274366928A5045705423 @default.
- W2274366928 hasAuthorship W2274366928A5080431101 @default.
- W2274366928 hasConcept C112930515 @default.
- W2274366928 hasConcept C12174686 @default.
- W2274366928 hasConcept C151730666 @default.
- W2274366928 hasConcept C2779343474 @default.
- W2274366928 hasConcept C2908647359 @default.
- W2274366928 hasConcept C33070731 @default.
- W2274366928 hasConcept C38652104 @default.
- W2274366928 hasConcept C39432304 @default.
- W2274366928 hasConcept C41008148 @default.
- W2274366928 hasConcept C71924100 @default.
- W2274366928 hasConcept C86803240 @default.
- W2274366928 hasConcept C99454951 @default.
- W2274366928 hasConceptScore W2274366928C112930515 @default.
- W2274366928 hasConceptScore W2274366928C12174686 @default.
- W2274366928 hasConceptScore W2274366928C151730666 @default.
- W2274366928 hasConceptScore W2274366928C2779343474 @default.
- W2274366928 hasConceptScore W2274366928C2908647359 @default.
- W2274366928 hasConceptScore W2274366928C33070731 @default.
- W2274366928 hasConceptScore W2274366928C38652104 @default.
- W2274366928 hasConceptScore W2274366928C39432304 @default.
- W2274366928 hasConceptScore W2274366928C41008148 @default.
- W2274366928 hasConceptScore W2274366928C71924100 @default.
- W2274366928 hasConceptScore W2274366928C86803240 @default.
- W2274366928 hasConceptScore W2274366928C99454951 @default.
- W2274366928 hasLocation W22743669281 @default.
- W2274366928 hasOpenAccess W2274366928 @default.
- W2274366928 hasPrimaryLocation W22743669281 @default.
- W2274366928 hasRelatedWork W104184982 @default.
- W2274366928 hasRelatedWork W107850551 @default.
- W2274366928 hasRelatedWork W1494458547 @default.
- W2274366928 hasRelatedWork W1588758970 @default.
- W2274366928 hasRelatedWork W2027577284 @default.
- W2274366928 hasRelatedWork W2028377213 @default.
- W2274366928 hasRelatedWork W2114062331 @default.
- W2274366928 hasRelatedWork W2146209266 @default.
- W2274366928 hasRelatedWork W2154060206 @default.
- W2274366928 hasRelatedWork W2167045999 @default.
- W2274366928 hasRelatedWork W2224612681 @default.
- W2274366928 hasRelatedWork W2281561530 @default.
- W2274366928 hasRelatedWork W2398251751 @default.
- W2274366928 hasRelatedWork W2592220837 @default.
- W2274366928 hasRelatedWork W2810692541 @default.
- W2274366928 hasRelatedWork W3134819462 @default.
- W2274366928 hasRelatedWork W3135493482 @default.
- W2274366928 hasRelatedWork W3213957692 @default.
- W2274366928 hasRelatedWork W1932972806 @default.
- W2274366928 hasRelatedWork W2479251561 @default.
- W2274366928 isParatext "false" @default.
- W2274366928 isRetracted "false" @default.
- W2274366928 magId "2274366928" @default.
- W2274366928 workType "article" @default.