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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274448498> ?p ?o ?g. }

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• W2274448498 abstract "In primary cultures of rat hepatocytes, specific thyroid-hormone-binding activity diminished with time and was hardly detectable at 24 h. In accordance with the loss of 3,5,3′-tri-iodothyronine (T3) binding, responses to the hormone disappeared, as indicated by low induction of the thyroid-hormone-responsive gene S14. In contrast, thyroid hormone receptor proteins were present, as determined by immunostaining with a specific antibody against the receptor. Thus the loss of T3 binding was due to receptor inactivation. After various attempts to restore the T3-binding activity, we found that 2-mercaptoethanol, a reducing agent, when added to the culture medium restored the hormone binding activity in a dose- and time-dependent manner. The observed kinetics and experiments using cycloheximide suggested that mercaptoethanol prevented inactivation of the newly synthesized receptors. Oxidoreductive conditions within cells may have a role in determining the level of activity of thyroid hormone receptors." @default.
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• W2274448498 date "1992-02-01" @default.
• W2274448498 modified "2023-09-27" @default.
• W2274448498 title "Loss of thyroid hormone receptor activity in primary cultured rat hepatocytes is reversed by 2-mercaptoethanol" @default.
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• W2274448498 doi "https://doi.org/10.1042/bj2810669" @default.
• W2274448498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1130743" @default.
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