Matches in SemOpenAlex for { <https://semopenalex.org/work/W22744567> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W22744567 endingPage "6" @default.
- W22744567 startingPage "1793" @default.
- W22744567 abstract "After IV, IM, and subcutaneous injection of single dosages of amikacin (5, 10, and 20 mg/kg of body weight) in each of 4 dogs, the elimination kinetics of amikacin were determined. The pattern of urinary excretion and cumulative amount excreted unchanged in 24 hours were also determined. Amikacin had a short half-life (approx 1 hour) that was independent of the dosage. Intravenous injection of 10 mg/kg gave apparent volume of distribution of 226 +/- 37 ml/kg and body clearance of 2.64 +/- 0.24 ml/min.kg (mean +/- SD, n = 4). Within 6 hours, greater than 90% of the antibiotic was excreted in the urine, regardless of the route of administration. For isolates of common bacterial species from the canine urinary tract, minimum inhibitory concentrations of amikacin, gentamicin, tobramycin, and kanamycin were determined in vitro. Cumulative percentages were approximately the same for urinary isolates of Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, and coagulase-positive staphylococci that were susceptible (minimum inhibitory concentrations less than or equal to 32 micrograms/ml) to increasing concentrations of amikacin, gentamicin, and tobramycin, in vitro. Klebsiella pneumoniae was significantly more susceptible to amikacin than were the other bacteria evaluated. Widest variations in susceptibility to aminoglycosides were found with urinary isolates of streptococcal species. For dogs with normal renal function, an amikacin dosage of 10 mg/kg (IM or subcutaneously) is recommended every 8 hours for treatment of systemic infections, and every 12 hours for treatment of urinary tract infections caused by susceptible bacteria." @default.
- W22744567 created "2016-06-24" @default.
- W22744567 creator A5057922574 @default.
- W22744567 creator A5079202604 @default.
- W22744567 creator A5080196760 @default.
- W22744567 date "1985-08-01" @default.
- W22744567 modified "2023-09-23" @default.
- W22744567 title "Clinical pharmacokinetics of amikacin in dogs." @default.
- W22744567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4037511" @default.
- W22744567 hasPublicationYear "1985" @default.
- W22744567 type Work @default.
- W22744567 sameAs 22744567 @default.
- W22744567 citedByCount "8" @default.
- W22744567 countsByYear W227445672012 @default.
- W22744567 countsByYear W227445672020 @default.
- W22744567 crossrefType "journal-article" @default.
- W22744567 hasAuthorship W22744567A5057922574 @default.
- W22744567 hasAuthorship W22744567A5079202604 @default.
- W22744567 hasAuthorship W22744567A5080196760 @default.
- W22744567 hasConcept C112705442 @default.
- W22744567 hasConcept C126322002 @default.
- W22744567 hasConcept C139254425 @default.
- W22744567 hasConcept C185592680 @default.
- W22744567 hasConcept C2775832221 @default.
- W22744567 hasConcept C2777427914 @default.
- W22744567 hasConcept C2777637488 @default.
- W22744567 hasConcept C2777787772 @default.
- W22744567 hasConcept C2778039505 @default.
- W22744567 hasConcept C2778974779 @default.
- W22744567 hasConcept C2780026642 @default.
- W22744567 hasConcept C501593827 @default.
- W22744567 hasConcept C523546767 @default.
- W22744567 hasConcept C54355233 @default.
- W22744567 hasConcept C71924100 @default.
- W22744567 hasConcept C77411442 @default.
- W22744567 hasConcept C86803240 @default.
- W22744567 hasConcept C89423630 @default.
- W22744567 hasConcept C98274493 @default.
- W22744567 hasConceptScore W22744567C112705442 @default.
- W22744567 hasConceptScore W22744567C126322002 @default.
- W22744567 hasConceptScore W22744567C139254425 @default.
- W22744567 hasConceptScore W22744567C185592680 @default.
- W22744567 hasConceptScore W22744567C2775832221 @default.
- W22744567 hasConceptScore W22744567C2777427914 @default.
- W22744567 hasConceptScore W22744567C2777637488 @default.
- W22744567 hasConceptScore W22744567C2777787772 @default.
- W22744567 hasConceptScore W22744567C2778039505 @default.
- W22744567 hasConceptScore W22744567C2778974779 @default.
- W22744567 hasConceptScore W22744567C2780026642 @default.
- W22744567 hasConceptScore W22744567C501593827 @default.
- W22744567 hasConceptScore W22744567C523546767 @default.
- W22744567 hasConceptScore W22744567C54355233 @default.
- W22744567 hasConceptScore W22744567C71924100 @default.
- W22744567 hasConceptScore W22744567C77411442 @default.
- W22744567 hasConceptScore W22744567C86803240 @default.
- W22744567 hasConceptScore W22744567C89423630 @default.
- W22744567 hasConceptScore W22744567C98274493 @default.
- W22744567 hasIssue "8" @default.
- W22744567 hasLocation W227445671 @default.
- W22744567 hasOpenAccess W22744567 @default.
- W22744567 hasPrimaryLocation W227445671 @default.
- W22744567 hasRelatedWork W2016042407 @default.
- W22744567 hasRelatedWork W2033569039 @default.
- W22744567 hasRelatedWork W2043451257 @default.
- W22744567 hasRelatedWork W2115593551 @default.
- W22744567 hasRelatedWork W2153594179 @default.
- W22744567 hasRelatedWork W224714992 @default.
- W22744567 hasRelatedWork W22744567 @default.
- W22744567 hasRelatedWork W2334769736 @default.
- W22744567 hasRelatedWork W2469521153 @default.
- W22744567 hasRelatedWork W2469823366 @default.
- W22744567 hasVolume "46" @default.
- W22744567 isParatext "false" @default.
- W22744567 isRetracted "false" @default.
- W22744567 magId "22744567" @default.
- W22744567 workType "article" @default.