Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274459560> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2274459560 abstract "We developed a new method to intermittently obstruct the airway in conscious rats to replicate the hypercapnea and respiratory effort characteristic of sleep apnea. A teflon tube (6 mm long, o.d. 2.5 mm, i.d. 2.1 mm) was inserted in the trachea of adult male rats. This tube contained the tip of an inflatable balloon catheter made from polyurethane tubing (10 cm long, o.d. 1.0 mm, i.d. 0.6 mm, Scientific Commodities, USA). The open end of the balloon catheter left the trachea through the incision, and was led subcutaneously to a metal connector that was externalized between the shoulder blades. Thus inflation of the balloon catheter closed the trachea without causing pain. Rats rapidly regained body weight after surgery and appeared healthy, although breathing occasionally was audible during the subsequent 1 – 2 months. Inflation of the balloon for 10 sec with 15 μL water caused forceful breathing movements. Heart rate became irregular and fell by up to 200 beats/min, and these effects were blocked by pretreatment with 3 mg atropine. Balloon inflation increased blood pressure by up to 40 mm Hg, and caused caused alertness, locomotion and rearing. These effects disappeared almost instantly after disinflation. Inflations repeated every 3 min gave reproducible cardiovascular changes. This method seems suitable for the analysis of the effects of chronic intermittent apnea. Financial support: FAPESP, CNPq." @default.
- W2274459560 created "2016-06-24" @default.
- W2274459560 creator A5016465573 @default.
- W2274459560 creator A5050254008 @default.
- W2274459560 creator A5074197154 @default.
- W2274459560 creator A5075682857 @default.
- W2274459560 date "2008-03-01" @default.
- W2274459560 modified "2023-10-01" @default.
- W2274459560 title "Intermittent obstructive apnea in conscious rats" @default.
- W2274459560 doi "https://doi.org/10.1096/fasebj.22.1_supplement.960.12" @default.
- W2274459560 hasPublicationYear "2008" @default.
- W2274459560 type Work @default.
- W2274459560 sameAs 2274459560 @default.
- W2274459560 citedByCount "0" @default.
- W2274459560 crossrefType "journal-article" @default.
- W2274459560 hasAuthorship W2274459560A5016465573 @default.
- W2274459560 hasAuthorship W2274459560A5050254008 @default.
- W2274459560 hasAuthorship W2274459560A5074197154 @default.
- W2274459560 hasAuthorship W2274459560A5075682857 @default.
- W2274459560 hasConcept C105922876 @default.
- W2274459560 hasConcept C139059822 @default.
- W2274459560 hasConcept C141071460 @default.
- W2274459560 hasConcept C178790620 @default.
- W2274459560 hasConcept C185592680 @default.
- W2274459560 hasConcept C2781267111 @default.
- W2274459560 hasConcept C2781326671 @default.
- W2274459560 hasConcept C2993470428 @default.
- W2274459560 hasConcept C42219234 @default.
- W2274459560 hasConcept C66098623 @default.
- W2274459560 hasConcept C71924100 @default.
- W2274459560 hasConceptScore W2274459560C105922876 @default.
- W2274459560 hasConceptScore W2274459560C139059822 @default.
- W2274459560 hasConceptScore W2274459560C141071460 @default.
- W2274459560 hasConceptScore W2274459560C178790620 @default.
- W2274459560 hasConceptScore W2274459560C185592680 @default.
- W2274459560 hasConceptScore W2274459560C2781267111 @default.
- W2274459560 hasConceptScore W2274459560C2781326671 @default.
- W2274459560 hasConceptScore W2274459560C2993470428 @default.
- W2274459560 hasConceptScore W2274459560C42219234 @default.
- W2274459560 hasConceptScore W2274459560C66098623 @default.
- W2274459560 hasConceptScore W2274459560C71924100 @default.
- W2274459560 hasFunder F4320320997 @default.
- W2274459560 hasFunder F4320322025 @default.
- W2274459560 hasIssue "S1" @default.
- W2274459560 hasLocation W22744595601 @default.
- W2274459560 hasOpenAccess W2274459560 @default.
- W2274459560 hasPrimaryLocation W22744595601 @default.
- W2274459560 hasRelatedWork W1979371157 @default.
- W2274459560 hasRelatedWork W1998929210 @default.
- W2274459560 hasRelatedWork W2015888339 @default.
- W2274459560 hasRelatedWork W2063961532 @default.
- W2274459560 hasRelatedWork W2067786156 @default.
- W2274459560 hasRelatedWork W2073816483 @default.
- W2274459560 hasRelatedWork W2158666179 @default.
- W2274459560 hasRelatedWork W2212370492 @default.
- W2274459560 hasRelatedWork W2396486013 @default.
- W2274459560 hasRelatedWork W2402148589 @default.
- W2274459560 hasVolume "22" @default.
- W2274459560 isParatext "false" @default.
- W2274459560 isRetracted "false" @default.
- W2274459560 magId "2274459560" @default.
- W2274459560 workType "article" @default.