Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274459670> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2274459670 endingPage "H869" @default.
- W2274459670 startingPage "H861" @default.
- W2274459670 abstract "The stiffness of rat cardiac trabeculae was measured in vitro to distinguish between an increase in unstimulated force (Fu) caused by rapid cycling of cross bridges or caused by rigor bridges during hypoxia. The force was measured with a strain gauge, the sarcomere length was determined by laser diffraction techniques, and muscle length was controlled by means of a motor. Stiffness was analyzed by using small (less than 1% of muscle length) sinusoidal length perturbations of 1 and 100 Hz. The stiffness at 100 Hz increased linearly with force during tetani at a varied [Sr2+] (0.25-10 mM) in the Krebs-Henseleit (K-H) buffer, but remained virtually unchanged at 1 Hz. In contrast, the stiffness of both the passive muscle and the muscle exposed to either CN- or to PO2 less than 1.5 mmHg up to development of maximal Fu (Fumax) was similar at 1- and 100-Hz perturbations. Less profound hypoxia (PO2 6-10 mmHg) resulted in spontaneous sarcomere activity during the rise in Fu, and an increase in the ratio of stiffness at 100 Hz to stiffness at 1 Hz was detected. When oxidative phosphorylation was inhibited by CN- (2 mM) while the muscle was stimulated in the absence of both Ca2+ and Na+ (choline+substituted), the addition of Na+ at the time at which Fu had reached 30-40% of Fumax did not affect the rate of rise of Fu. These results show that the development of Fu during more complete anoxia in rat trabeculae is completely due to the formation of rigor links and that Ca2(+)-dependent cross-bridge activation can contribute to the rise in Fu during less severe hypoxia." @default.
- W2274459670 created "2016-06-24" @default.
- W2274459670 creator A5045196813 @default.
- W2274459670 creator A5081763167 @default.
- W2274459670 creator A5087790272 @default.
- W2274459670 date "1990-03-01" @default.
- W2274459670 modified "2023-09-27" @default.
- W2274459670 title "Unstimulated force during hypoxia of rat cardiac muscle: stiffness and calcium dependence" @default.
- W2274459670 doi "https://doi.org/10.1152/ajpheart.1990.258.3.h861" @default.
- W2274459670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2316700" @default.
- W2274459670 hasPublicationYear "1990" @default.
- W2274459670 type Work @default.
- W2274459670 sameAs 2274459670 @default.
- W2274459670 citedByCount "7" @default.
- W2274459670 crossrefType "journal-article" @default.
- W2274459670 hasAuthorship W2274459670A5045196813 @default.
- W2274459670 hasAuthorship W2274459670A5081763167 @default.
- W2274459670 hasAuthorship W2274459670A5087790272 @default.
- W2274459670 hasConcept C105702510 @default.
- W2274459670 hasConcept C12554922 @default.
- W2274459670 hasConcept C126322002 @default.
- W2274459670 hasConcept C159985019 @default.
- W2274459670 hasConcept C178790620 @default.
- W2274459670 hasConcept C185592680 @default.
- W2274459670 hasConcept C192562407 @default.
- W2274459670 hasConcept C207200792 @default.
- W2274459670 hasConcept C2778996579 @default.
- W2274459670 hasConcept C2779372316 @default.
- W2274459670 hasConcept C2993843704 @default.
- W2274459670 hasConcept C519063684 @default.
- W2274459670 hasConcept C540031477 @default.
- W2274459670 hasConcept C68731436 @default.
- W2274459670 hasConcept C71924100 @default.
- W2274459670 hasConcept C7836513 @default.
- W2274459670 hasConcept C86803240 @default.
- W2274459670 hasConceptScore W2274459670C105702510 @default.
- W2274459670 hasConceptScore W2274459670C12554922 @default.
- W2274459670 hasConceptScore W2274459670C126322002 @default.
- W2274459670 hasConceptScore W2274459670C159985019 @default.
- W2274459670 hasConceptScore W2274459670C178790620 @default.
- W2274459670 hasConceptScore W2274459670C185592680 @default.
- W2274459670 hasConceptScore W2274459670C192562407 @default.
- W2274459670 hasConceptScore W2274459670C207200792 @default.
- W2274459670 hasConceptScore W2274459670C2778996579 @default.
- W2274459670 hasConceptScore W2274459670C2779372316 @default.
- W2274459670 hasConceptScore W2274459670C2993843704 @default.
- W2274459670 hasConceptScore W2274459670C519063684 @default.
- W2274459670 hasConceptScore W2274459670C540031477 @default.
- W2274459670 hasConceptScore W2274459670C68731436 @default.
- W2274459670 hasConceptScore W2274459670C71924100 @default.
- W2274459670 hasConceptScore W2274459670C7836513 @default.
- W2274459670 hasConceptScore W2274459670C86803240 @default.
- W2274459670 hasIssue "3" @default.
- W2274459670 hasLocation W22744596701 @default.
- W2274459670 hasLocation W22744596702 @default.
- W2274459670 hasOpenAccess W2274459670 @default.
- W2274459670 hasPrimaryLocation W22744596701 @default.
- W2274459670 hasRelatedWork W2017318166 @default.
- W2274459670 hasRelatedWork W2043144643 @default.
- W2274459670 hasRelatedWork W2046412711 @default.
- W2274459670 hasRelatedWork W2049501604 @default.
- W2274459670 hasRelatedWork W2059796874 @default.
- W2274459670 hasRelatedWork W2065226164 @default.
- W2274459670 hasRelatedWork W2071225392 @default.
- W2274459670 hasRelatedWork W2110538544 @default.
- W2274459670 hasRelatedWork W2461420448 @default.
- W2274459670 hasRelatedWork W4313461941 @default.
- W2274459670 hasVolume "258" @default.
- W2274459670 isParatext "false" @default.
- W2274459670 isRetracted "false" @default.
- W2274459670 magId "2274459670" @default.
- W2274459670 workType "article" @default.