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• W2274558413 abstract "The effect of delayed vagal activity withdrawal on cardiorespiratory responses at an increase in workload was examined. Eleven volunteers (21 ± 3 yr, 66 ± 4 kg) performed cycle ergometer exercise at a work rate corresponding to 80% of ventilatory threshold after 3 min of unloaded cycling. Facial stimulation was given by applying a vinyl bag filled with cold water (3–5°C) to the face 1 min before to 1 min after the increase in workload (S2 trial) or no stimulation was given (Nr trial). Oxygen uptake (V˙o 2 ), heart rate (HR), and cardiac output (Q˙) were continuously recorded in four transitions for each trial. Data were averaged for each subject and trial. Mean response time (MRT, sum of delay and time constant) was calculated with a monoexponential fitting. Facial stimulation induced acute bradycardia (−10 ± 5 beats/min in S2 trial). The MRT of HR and Q˙ was significantly longer in the S2 trials (46 ± 35 and 37 ± 23 s) than in the Nr trials (26 ± 18 and 28 ± 19 s, respectively), but no significant change inV˙o 2 MRT was shown (36 ± 7 vs. 38 ± 12 s). These findings suggest that increased vagal activity delays the central circulatory responses, which does not alter the V˙o 2 kinetics at the onset of stepwise increase in workload. The maintenance ofV˙o 2 kinetics during acute bradycardia may either reflect the fact that some intramuscular processes (such as oxidative enzyme inertia) limitV˙o 2 kinetics or alternatively that increased sympathetic vasoconstriction at some remote site defends exercising muscle blood flow." @default.
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• W2274558413 date "1998-05-01" @default.
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• W2274558413 title "Delayed vagal withdrawal slows circulatory but not oxygen uptake responses at work increase" @default.
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• W2274558413 doi "https://doi.org/10.1152/ajpregu.1998.274.5.r1268" @default.
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