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• W2274564376 abstract "The actions of dopamine are mediated by 5 or more receptor subtypes, any ofwhich may be coupled by G-proteins to adenylate cyclase (D1-family: stimulatory, D2-family: inhibitory or no action). Postnatal ocular growth in the chick is a vision-dependent mechanism which involves D2-type receptors in either the retina or the retinal pigment epithelium (RPE). Although the dopaminergic amacrine cells are well described in the chick retina, only D2-receptors, but not D3- and D4-receptors have been clearly localized, and the cells that express them have not been identified. In this study we showed that immunoreactive D23-receptor protein is localized to the photoreceptor inner segments, outer and inner plexiform layer and ganglion cell layer, as described previously (Wagner et al., J. Comp. Neurol., 330 (1993) 1–13). D2-receptor mRNA was localized to cell bodies in all nuclear layers of the retina, whereas D4-receptor mRNA was restricted to the inner half of the retina. Immunoreactive D2-type receptors and their mRNA were observed also in the basal region of the RPE. because of the widespread distribution of both D2- and D4-receptor mRNA in the chick retina and RPE and the lack of D3- and D4-receptor-specific antibodies, we were unable to identify which of the D2/34-receptor-bearing cells are involved in controlling ocular growth." @default.
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• W2274564376 date "1995-10-01" @default.
• W2274564376 modified "2023-09-23" @default.
• W2274564376 title "Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry" @default.
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• W2274564376 doi "https://doi.org/10.1016/0006-8993(95)00700-z" @default.
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