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- W2274592652 endingPage "736" @default.
- W2274592652 startingPage "721" @default.
- W2274592652 abstract "Mitochondria, essential to multicellular life, convert food into ATP to satisfy cellular energy demands. Since different tissues have different energy requirements, mitochondrial density is high in tissues with high metabolic needs, such as the visual system, which is therefore highly susceptible to limited energy supply as a result of mitochondrial dysfunction.Vision impairment is a common feature of most mitochondrial diseases. At the same time, there is mounting evidence that mitochondrial impairment contributes to the pathogenesis of major eye diseases such as glaucoma and might also be involved in the reported vision impairment in neurodegenerative disorders such as Alzheimer's disease.Rather than relying on symptomatic treatment, acknowledging the mitochondrial origin of visual disorders in mitochondrial, neurodegenerative and ocular diseases could lead to novel therapeutics that aim to modulate mitochondrial function in order to protect against vision loss. This approach has already shown some promising clinical results in inherited retinal disorders, which supports the idea that targeting mitochondria could also be a treatment option for other optic neuropathies." @default.
- W2274592652 created "2016-06-24" @default.
- W2274592652 creator A5068572356 @default.
- W2274592652 creator A5069996839 @default.
- W2274592652 date "2016-01-13" @default.
- W2274592652 modified "2023-09-24" @default.
- W2274592652 title "Targeting mitochondrial function to protect against vision loss" @default.
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