Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274663523> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2274663523 abstract "This thesis firstly reports on the development and characterization of reagent-less and cobalt(III) sepulchrate[Co(Sep)³⁺] mediated biosensor platforms (biosensor platform 1 and biosensor platform 2), with human recombinant heme thiolate, cytochrome P450 3A4 isoenzyme (CYP3A4), as biorecognition component. Secondly, each biosensor platform was evaluated by using an entirely different category of compound as model substrate, with the overall objective being the development of alternative analytical method for the detection and quantification of each of these substrates,by amperometric transduction method. In this regard biosensor platform 1 was evaluated for the detection of 2,4-dichlorophenol, whereas biosensor platform 2 was evaluated for the detection of protease inhibitor (PI) HAART drug, indinavir. Fourthly, this dissertation also reports on the use of genetic engineering as complimentary method during biosensor investigations, as source for continuous supply of catalytically active biological recognition component. With respect to the preparation of the biosensors in particular, biosensor platform 1 was constructed by entrapping the commercially sourced full-length, wild type CYP3A4 on a pre-formed electroactive carrier matrix, consisting of Co(Sep)³⁺–modified nafion membrane on a glassy carbon electrode. In this regard, the nafion-Co(Sep)³⁺ composite was prepared by integrating the Co(Sep)³⁺ species into a pre-formed nafion film through manual drop-coating and mixing methods." @default.
- W2274663523 created "2016-06-24" @default.
- W2274663523 creator A5052814350 @default.
- W2274663523 date "2010-01-01" @default.
- W2274663523 modified "2023-09-22" @default.
- W2274663523 title "Electrochemical dynamics of cytochrome P450-3A4 isoenzyme biosensor for protease inhibitor antiretroviral drug" @default.
- W2274663523 hasPublicationYear "2010" @default.
- W2274663523 type Work @default.
- W2274663523 sameAs 2274663523 @default.
- W2274663523 citedByCount "0" @default.
- W2274663523 crossrefType "dissertation" @default.
- W2274663523 hasAuthorship W2274663523A5052814350 @default.
- W2274663523 hasConcept C147789679 @default.
- W2274663523 hasConcept C160756335 @default.
- W2274663523 hasConcept C17525397 @default.
- W2274663523 hasConcept C185592680 @default.
- W2274663523 hasConcept C203014093 @default.
- W2274663523 hasConcept C2776452011 @default.
- W2274663523 hasConcept C2777210460 @default.
- W2274663523 hasConcept C2778665636 @default.
- W2274663523 hasConcept C2780727368 @default.
- W2274663523 hasConcept C3013748606 @default.
- W2274663523 hasConcept C43617362 @default.
- W2274663523 hasConcept C52859227 @default.
- W2274663523 hasConcept C55493867 @default.
- W2274663523 hasConcept C86803240 @default.
- W2274663523 hasConceptScore W2274663523C147789679 @default.
- W2274663523 hasConceptScore W2274663523C160756335 @default.
- W2274663523 hasConceptScore W2274663523C17525397 @default.
- W2274663523 hasConceptScore W2274663523C185592680 @default.
- W2274663523 hasConceptScore W2274663523C203014093 @default.
- W2274663523 hasConceptScore W2274663523C2776452011 @default.
- W2274663523 hasConceptScore W2274663523C2777210460 @default.
- W2274663523 hasConceptScore W2274663523C2778665636 @default.
- W2274663523 hasConceptScore W2274663523C2780727368 @default.
- W2274663523 hasConceptScore W2274663523C3013748606 @default.
- W2274663523 hasConceptScore W2274663523C43617362 @default.
- W2274663523 hasConceptScore W2274663523C52859227 @default.
- W2274663523 hasConceptScore W2274663523C55493867 @default.
- W2274663523 hasConceptScore W2274663523C86803240 @default.
- W2274663523 hasLocation W22746635231 @default.
- W2274663523 hasOpenAccess W2274663523 @default.
- W2274663523 hasPrimaryLocation W22746635231 @default.
- W2274663523 hasRelatedWork W1965200308 @default.
- W2274663523 hasRelatedWork W1987676946 @default.
- W2274663523 hasRelatedWork W2036405268 @default.
- W2274663523 hasRelatedWork W2043919627 @default.
- W2274663523 hasRelatedWork W2070669870 @default.
- W2274663523 hasRelatedWork W2377023375 @default.
- W2274663523 hasRelatedWork W2799736741 @default.
- W2274663523 hasRelatedWork W2903606940 @default.
- W2274663523 hasRelatedWork W2949922799 @default.
- W2274663523 hasRelatedWork W3048571004 @default.
- W2274663523 hasRelatedWork W3092103328 @default.
- W2274663523 hasRelatedWork W3214678864 @default.
- W2274663523 hasRelatedWork W752707691 @default.
- W2274663523 hasRelatedWork W842612800 @default.
- W2274663523 hasRelatedWork W186109339 @default.
- W2274663523 hasRelatedWork W2730363633 @default.
- W2274663523 hasRelatedWork W2815264654 @default.
- W2274663523 hasRelatedWork W2819297662 @default.
- W2274663523 hasRelatedWork W2823566253 @default.
- W2274663523 hasRelatedWork W2923392305 @default.
- W2274663523 isParatext "false" @default.
- W2274663523 isRetracted "false" @default.
- W2274663523 magId "2274663523" @default.
- W2274663523 workType "dissertation" @default.