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- W2274750278 abstract "Cyclosporine (CyS) has been shown to inhibit activation of human T lymphocytes. A cascade of interactions involving Interleukin 2 (IL2), Interleukin 2 receptor (IL2R) and transferrin receptor (TR) is necessary for activation. In studies using peripheral blood mononuclear cells obtained from healthy donors, the authors measured the expression of IL2 and TR (using receptor-specific monoclonal antibodies and flow cytometry) and DNA synthesis (/sup 3/-thymidine incorporation) in response to PHA, OKT3, Leu 4 or Con A. In the presence of CyS (0.5 ..mu..g/ml) expression of IL2R and TR as well as DNA synthesis were markedly reduced. Upon serial dilutions of CyS, changes in DNA synthesis in response to OKT3 reflected changes in IL2R and TR levels, indicating all 3 parameters may be interrelated. Addition of exogenous IL2 partially abrogated the inhibitory effect of CyS on these activation parameters in response to PHA, OKT3 and Leu 4 but not to Con A. The authors results suggest that CyS is an effective inhibitor of mitogen-induced expression of IL2R and TR and that exogenous IL2 partially reverses this inhibitory effect." @default.
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- W2274750278 date "1986-03-05" @default.
- W2274750278 modified "2023-09-26" @default.
- W2274750278 title "Cyclosporine inhibits expression of receptors for interleukin 2 and transferrin on mitogen-activated human T lymphocytes" @default.
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