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- W2274841487 abstract "Uterine transplantation is a potential option to treat uterine factor infertility. Mycophenolate mofetil (MMF) is a powerful immunosuppressive agent that is currently used in uterine transplantation. However ischemia/reperfusion (I/R) injury has a detrimental effect on early allograft dysfunction in organ transplanted patients. Therefore we aimed to investigate whether MMF could attenuate uterine I/R injury. Experimental study. 28 female Wistar rats used for all experiments. Group I (M): underwent sham surgery and received 20 mg/kg/day MMF (0.5% sodium carboxymethylcellulose), Group 2 (C): underwent sham surgery and received vehicle control, Group 3 (IR+V): underwent uterine I/R procedure and received vehicle control, Group 4 (IR+M): underwent uterine I/R procedure and received 20 mg/kg/day MMF. All treatments were conducted by gavage and started 5 days before surgery and maintained until uteri were removed. Ischemia reperfusion was conducted for 30 minutes. Specifically ischemia was created by clamping the distal abdominal aorta followed by 4 hours reperfusion. Uterine tissue ischemia modified albumin (IMA), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and miyeloperoxidase (MPO) levels were determined as markers of oxidative injury. 8 hydroxydeoxyguanosine (8-OHdG) was investigated to evaluate the levels of oxidative DNA injury. Histopathologic examination were conducted following hematoxylin-eosin staining. Histologic examination of IR+M group had more regular endometrial contours, glands and less polymorphonuclear cell infiltration than the IR+V group. Pretreatment with MMF attenuates I/R injury. This protection may have occurred by an anti-inflammatory and antioxidant effect. Therefore MMF used as part of an immunosuppressant regimen may also provide a cytoprotective effect against uterine warm ischemia injury.Tabled 1Table 1. The levels of oxidative injury and DNA injury markers.GroupsCIR+VIR+MIMA (U/mL)0.23 ± 0.050.56 ± 0.08*0.41 ± 0.07*#GSH (umol/mg protein)2.31 ± 0.351.74 ± 0.23*1.88 ± 0.20MDA (mmol/mg protein)10.5 ±1.5015.96 ± 1.21**12.13 ± 1.14##MPO (U/mg protein)1.60 ± 0.436.27 ±2.26*3.05 ± 0.70*#SOD (U/mg protein)4.95 ± 1.391.98 ± 0.45**3.76 ± 1.308OHdG (ng/ug DNA)1.06 ± 0.121.82 ± 0.40*1.22 ± 0.12#Data are shown mean ± SD. * P<0.01, **P<0.001 versus C group; #P<0.01, ##P<0.001 versus IR+V group. Open table in a new tab" @default.
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- W2274841487 date "2015-09-01" @default.
- W2274841487 modified "2023-10-18" @default.
- W2274841487 title "Donor treatment with mycophenolate mofetil attenuates uterine ischemia/reperfusion injury" @default.
- W2274841487 doi "https://doi.org/10.1016/j.fertnstert.2015.07.536" @default.
- W2274841487 hasPublicationYear "2015" @default.
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