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- W2274865219 abstract "Abstract Background & Aims Interferon and ribavirin‐free regimens to treat chronic hepatitis C virus (HCV) infection in patients with end stage renal disease are not approved and represent an area of unmet clinical need. We report our experience on the safety and efficacy of sofosbuvir/simeprevir and sofosbuvir/ledipasvir therapy in patients on haemodialysis. Methods Patients with chronic HCV infection on haemodialysis were included in this study. Patients were started on either sofosbuvir/simeprevir or sofosbuvir/ledipasvir. Routine clinical and laboratory data were collected at baseline and during treatment. The primary outcome was sustained virological response at week 12 ( SVR 12). Results Eight patients with mean age 56.8 ± 20 years were included in this study. Seven were treatment naïve and one was a priori null responder to interferon‐based therapy. Four patients were started on sofosbuvir/simeprevir and four on sofosbuvir/ledipasvir for 12 weeks. Therapy was well tolerated overall with nausea/vomiting, pruritus, headache and a 2 g/dl drop in haemoglobin developing in one patient each. No patient discontinued therapy because of side effects. Comparison of labs at baseline and nadir levels during treatment revealed no significant change in haemoglobin (10.8 ± 2.4 g/dl vs 10.3 ± 1.6 g/dl), platelet count (198 ± 164 k/μl vs 184.5 ± 162/μl) and bilirubin (0.3 ± 0.4 mg/dl vs 0.25 ± 0.15 mg/dl). Eight of eight patients had undetectable HCV RNA at the end of treatment. One patient was lost to follow up and the remaining seven achieved SVR12. Conclusion Full dose sofosbuvir/simeprevir or sofosbuvir/ledipasvir therapy for HCV ‐infected patients with end stage renal disease was well tolerated with no discontinuation owing to side effects and no significant adverse events." @default.
- W2274865219 created "2016-06-24" @default.
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- W2274865219 date "2016-02-22" @default.
- W2274865219 modified "2023-10-03" @default.
- W2274865219 title "Sofosbuvir‐based treatment is safe and effective in patients with chronic hepatitis C infection and end stage renal disease: a case series" @default.
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- W2274865219 doi "https://doi.org/10.1111/liv.13078" @default.
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