Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274920250> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2274920250 endingPage "693" @default.
- W2274920250 startingPage "687" @default.
- W2274920250 abstract "The addition of an ultrafiltration step to the purification procedures previously described for cholera toxin (Rappaport et al., (1974) permitted the preparation of highly purified antigenic toxoids essentially free of somatic antigen(s). The purity of such toxoids is established: (i) by the absence of more than about one part limulus amebocyte lysate (LAL)-positive endotoxin per 10(5) parts toxoid and (ii) by the inability of the toxoids to elicit a significant rise in rabbit vibriocidal antibody. The antigenicity of the toxoids is demonstrated by their ability to produce the same high levels of rabbit serum antitoxin as are produced by comparable toxoids containing small amounts of somatic antigen. The results also indicate that amounts of somatic antigen of the order of less than or equal to 1 mug/100 mug of toxoid do not exert an adjuvant effect on the toxoid, at least with respect to circulating antitoxin. Other data show that, where present, the ability of somatic antigen to elicit vibriocidal antibody is influenced by the immunization schedule employed and that a correlation exists between the LAL-determined endotoxin content of the toxoids and their ability to stimulate vibriocidal antibody. Somatic antigen-free toxoids, purified and tested by the refinements herein described, were prepared for use in the National Institutes of Health sponsored field trials, and data pertaining to their purity and antigenic properties are presented." @default.
- W2274920250 created "2016-06-24" @default.
- W2274920250 creator A5009012577 @default.
- W2274920250 creator A5040081738 @default.
- W2274920250 creator A5056095596 @default.
- W2274920250 creator A5065635878 @default.
- W2274920250 creator A5077438051 @default.
- W2274920250 date "1976-09-01" @default.
- W2274920250 modified "2023-09-24" @default.
- W2274920250 title "Development of a purified cholera toxoid. III. Refinements in purification of toxin and methods for the determination of residual somatic antigen" @default.
- W2274920250 cites W1775749144 @default.
- W2274920250 cites W1834959171 @default.
- W2274920250 cites W1901677999 @default.
- W2274920250 cites W2014482345 @default.
- W2274920250 cites W2085717873 @default.
- W2274920250 cites W2583039306 @default.
- W2274920250 doi "https://doi.org/10.1128/iai.14.3.687-693.1976" @default.
- W2274920250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/420941" @default.
- W2274920250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/823117" @default.
- W2274920250 hasPublicationYear "1976" @default.
- W2274920250 type Work @default.
- W2274920250 sameAs 2274920250 @default.
- W2274920250 citedByCount "12" @default.
- W2274920250 crossrefType "journal-article" @default.
- W2274920250 hasAuthorship W2274920250A5009012577 @default.
- W2274920250 hasAuthorship W2274920250A5040081738 @default.
- W2274920250 hasAuthorship W2274920250A5056095596 @default.
- W2274920250 hasAuthorship W2274920250A5065635878 @default.
- W2274920250 hasAuthorship W2274920250A5077438051 @default.
- W2274920250 hasBestOaLocation W22749202501 @default.
- W2274920250 hasConcept C10389963 @default.
- W2274920250 hasConcept C12590561 @default.
- W2274920250 hasConcept C147483822 @default.
- W2274920250 hasConcept C14909468 @default.
- W2274920250 hasConcept C159047783 @default.
- W2274920250 hasConcept C159654299 @default.
- W2274920250 hasConcept C203014093 @default.
- W2274920250 hasConcept C22070199 @default.
- W2274920250 hasConcept C2777006276 @default.
- W2274920250 hasConcept C2777351567 @default.
- W2274920250 hasConcept C2777367657 @default.
- W2274920250 hasConcept C2778973234 @default.
- W2274920250 hasConcept C2779026604 @default.
- W2274920250 hasConcept C2780572238 @default.
- W2274920250 hasConcept C2780722889 @default.
- W2274920250 hasConcept C2780801004 @default.
- W2274920250 hasConcept C86803240 @default.
- W2274920250 hasConcept C89423630 @default.
- W2274920250 hasConceptScore W2274920250C10389963 @default.
- W2274920250 hasConceptScore W2274920250C12590561 @default.
- W2274920250 hasConceptScore W2274920250C147483822 @default.
- W2274920250 hasConceptScore W2274920250C14909468 @default.
- W2274920250 hasConceptScore W2274920250C159047783 @default.
- W2274920250 hasConceptScore W2274920250C159654299 @default.
- W2274920250 hasConceptScore W2274920250C203014093 @default.
- W2274920250 hasConceptScore W2274920250C22070199 @default.
- W2274920250 hasConceptScore W2274920250C2777006276 @default.
- W2274920250 hasConceptScore W2274920250C2777351567 @default.
- W2274920250 hasConceptScore W2274920250C2777367657 @default.
- W2274920250 hasConceptScore W2274920250C2778973234 @default.
- W2274920250 hasConceptScore W2274920250C2779026604 @default.
- W2274920250 hasConceptScore W2274920250C2780572238 @default.
- W2274920250 hasConceptScore W2274920250C2780722889 @default.
- W2274920250 hasConceptScore W2274920250C2780801004 @default.
- W2274920250 hasConceptScore W2274920250C86803240 @default.
- W2274920250 hasConceptScore W2274920250C89423630 @default.
- W2274920250 hasIssue "3" @default.
- W2274920250 hasLocation W22749202501 @default.
- W2274920250 hasLocation W22749202502 @default.
- W2274920250 hasOpenAccess W2274920250 @default.
- W2274920250 hasPrimaryLocation W22749202501 @default.
- W2274920250 hasRelatedWork W1914790964 @default.
- W2274920250 hasRelatedWork W1933396433 @default.
- W2274920250 hasRelatedWork W1966309523 @default.
- W2274920250 hasRelatedWork W2080665274 @default.
- W2274920250 hasRelatedWork W2113968399 @default.
- W2274920250 hasRelatedWork W2121963792 @default.
- W2274920250 hasRelatedWork W2170871724 @default.
- W2274920250 hasRelatedWork W2274920250 @default.
- W2274920250 hasRelatedWork W2283959817 @default.
- W2274920250 hasRelatedWork W2418393266 @default.
- W2274920250 hasVolume "14" @default.
- W2274920250 isParatext "false" @default.
- W2274920250 isRetracted "false" @default.
- W2274920250 magId "2274920250" @default.
- W2274920250 workType "article" @default.