FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274920295> ?p ?o ?g. }

• W2274920295 endingPage "786" @default.
• W2274920295 startingPage "781" @default.
• W2274920295 abstract "Disruption of the murine mdr2 gene leads to the complete absence of biliary phospholipids. We tested the hypothesis that the increase in biliary phospholipid output induced by fibrates is mediated via induction of the hepatic mdr2 gene and its encoded product, the P-glucoprotein canalicular flippase. Increased levels of mdr2 mRNA were observed in the liver of mice treated with different fibrates: ciprofibrate, 660+/-155% (as compared with control group); clofibrate, 611+/-77%; bezafibrate, 410+/-47%; fenofibrate, 310+/-52%; gemfibrozil, 190+/-25% (P <0.05 compared with control group). Induction of expression of the mdr gene family was specific to the mdr2 gene. Two- to three-fold increases in P-glycoprotein immunodetection were evident on the canalicular plasma-membrane domain of clofibrate- and ciprofibrate-treated mice. Biliary phospholipid output increased from 4.2+/-1.2 nmol/min per g of liver in the control group to 8.5+/-0.6, 7.1+/-2.9 and 5.8+/-2.5 in ciprofibrate-, clofibrate- and bezafibrate-treated mice respectively (P <0.05 compared with control group). Moreover, a significant correlation between biliary phospholipid output and the relative levels of mdr2 mRNA was found (r=0.86; P <0.05). In treated animals, bile flow as well as cholesterol and bile acid outputs remained unchanged. Our findings constitute the first evidence that pharmacological modulation of biliary lipid secretion mediated by fibrates can be related to the overexpression of a specific liver gene product, the mdr2 P-glycoprotein, and are consistent with the hypothesis that the mdr2 P-glycoprotein isoform plays a crucial role in the secretion of biliary phospholipid." @default.
• W2274920295 created "2016-06-24" @default.
• W2274920295 creator A5002520777 @default.
• W2274920295 creator A5005759073 @default.
• W2274920295 creator A5013891301 @default.
• W2274920295 creator A5032099803 @default.
• W2274920295 creator A5035253926 @default.
• W2274920295 creator A5040484564 @default.
• W2274920295 creator A5042691308 @default.
• W2274920295 creator A5049145516 @default.
• W2274920295 creator A5052413133 @default.
• W2274920295 creator A5062139224 @default.
• W2274920295 date "1996-03-15" @default.
• W2274920295 modified "2023-09-26" @default.
• W2274920295 title "Fibrates induce <i>mdr2</i> gene expression and biliary phospholipid secretion in the mouse" @default.
• W2274920295 cites W109313831 @default.
• W2274920295 cites W1513685218 @default.
• W2274920295 cites W1573935872 @default.
• W2274920295 cites W1605451242 @default.
• W2274920295 cites W1606277396 @default.
• W2274920295 cites W1775749144 @default.
• W2274920295 cites W1849989959 @default.
• W2274920295 cites W1858200607 @default.
• W2274920295 cites W1865504766 @default.
• W2274920295 cites W1923579966 @default.
• W2274920295 cites W1963552073 @default.
• W2274920295 cites W1964470226 @default.
• W2274920295 cites W2007931369 @default.
• W2274920295 cites W2011629121 @default.
• W2274920295 cites W2014669590 @default.
• W2274920295 cites W2018289835 @default.
• W2274920295 cites W2028533496 @default.
• W2274920295 cites W2034448667 @default.
• W2274920295 cites W2037621239 @default.
• W2274920295 cites W2051921241 @default.
• W2274920295 cites W2054982983 @default.
• W2274920295 cites W2062167428 @default.
• W2274920295 cites W2065114140 @default.
• W2274920295 cites W2074058488 @default.
• W2274920295 cites W2082064626 @default.
• W2274920295 cites W2094974920 @default.
• W2274920295 cites W2097878215 @default.
• W2274920295 cites W2098628139 @default.
• W2274920295 cites W2100837269 @default.
• W2274920295 cites W2109162773 @default.
• W2274920295 cites W2112001901 @default.
• W2274920295 cites W2118234018 @default.
• W2274920295 cites W2129277820 @default.
• W2274920295 cites W2134812217 @default.
• W2274920295 cites W2145607198 @default.
• W2274920295 cites W2153054877 @default.
• W2274920295 cites W2156631664 @default.
• W2274920295 cites W2161221148 @default.
• W2274920295 cites W2162097287 @default.
• W2274920295 cites W2172134989 @default.
• W2274920295 cites W2195262735 @default.
• W2274920295 cites W2416679100 @default.
• W2274920295 cites W2425983524 @default.
• W2274920295 cites W2615953705 @default.
• W2274920295 cites W4210996660 @default.
• W2274920295 doi "https://doi.org/10.1042/bj3140781" @default.
• W2274920295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217124" @default.
• W2274920295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8615769" @default.
• W2274920295 hasPublicationYear "1996" @default.
• W2274920295 type Work @default.
• W2274920295 sameAs 2274920295 @default.
• W2274920295 citedByCount "136" @default.
• W2274920295 countsByYear W22749202952012 @default.
• W2274920295 countsByYear W22749202952013 @default.
• W2274920295 countsByYear W22749202952014 @default.
• W2274920295 countsByYear W22749202952015 @default.
• W2274920295 countsByYear W22749202952016 @default.
• W2274920295 countsByYear W22749202952017 @default.
• W2274920295 countsByYear W22749202952018 @default.
• W2274920295 countsByYear W22749202952019 @default.
• W2274920295 countsByYear W22749202952020 @default.
• W2274920295 countsByYear W22749202952021 @default.
• W2274920295 countsByYear W22749202952022 @default.
• W2274920295 countsByYear W22749202952023 @default.
• W2274920295 crossrefType "journal-article" @default.
• W2274920295 hasAuthorship W2274920295A5002520777 @default.
• W2274920295 hasAuthorship W2274920295A5005759073 @default.
• W2274920295 hasAuthorship W2274920295A5013891301 @default.
• W2274920295 hasAuthorship W2274920295A5032099803 @default.
• W2274920295 hasAuthorship W2274920295A5035253926 @default.
• W2274920295 hasAuthorship W2274920295A5040484564 @default.
• W2274920295 hasAuthorship W2274920295A5042691308 @default.
• W2274920295 hasAuthorship W2274920295A5049145516 @default.
• W2274920295 hasAuthorship W2274920295A5052413133 @default.
• W2274920295 hasAuthorship W2274920295A5062139224 @default.
• W2274920295 hasBestOaLocation W22749202952 @default.
• W2274920295 hasConcept C126322002 @default.
• W2274920295 hasConcept C133936738 @default.
• W2274920295 hasConcept C134018914 @default.
• W2274920295 hasConcept C185592680 @default.
• W2274920295 hasConcept C2776362216 @default.
• W2274920295 hasConcept C2778110834 @default.
• W2274920295 hasConcept C2778163477 @default.

• next