FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274981103> ?p ?o ?g. }

• W2274981103 endingPage "352" @default.
• W2274981103 startingPage "344" @default.
• W2274981103 abstract "Proton beam therapy has been gaining popularity in the management of a wide spectrum of cancers. However, little is known about the effect of proton beams on epigenetic alterations. In this study, the effects of proton beams on DNA methylation were evaluated in the breast cell lines MCF-10A and MCF-7. Pyrosequencing analysis of the long interspersed element 1 (LINE1) gene indicated that a few specific CpG sites were induced to be hypermethylated by proton beam treatment from 64.5 to 76.5% and from 57.7 to 60.0% (p < 0.05) in MCF-10A and MCF-7, respectively. Genome-wide methylation analysis identified Developmental Disorder, Hereditary Disorder, Metabolic Disease as the top network in the MCF-7 cell line. The proliferation rate significantly decreased in proton beam-treated cells, as judged by colony formation and cell proliferation assay. Upon treatment with the proton beam, expression of selected genes (MDH2, STYXL1, CPE, FAM91A1, and GPR37) was significantly changed in accordance with the changes of methylation level. Taken together, the findings demonstrate that proton beam-induced physiological changes of cancer cells via methylation modification assists in establishing the epigenetic basis of proton beam therapy for cancer." @default.
• W2274981103 created "2016-06-24" @default.
• W2274981103 creator A5009191874 @default.
• W2274981103 creator A5036143991 @default.
• W2274981103 creator A5073015534 @default.
• W2274981103 creator A5083484723 @default.
• W2274981103 creator A5086667271 @default.
• W2274981103 creator A5087792818 @default.
• W2274981103 creator A5091107907 @default.
• W2274981103 date "2016-01-01" @default.
• W2274981103 modified "2023-10-11" @default.
• W2274981103 title "Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation Status" @default.
• W2274981103 cites W1522855936 @default.
• W2274981103 cites W153023584 @default.
• W2274981103 cites W1567922991 @default.
• W2274981103 cites W1916834316 @default.
• W2274981103 cites W1964168560 @default.
• W2274981103 cites W1967596017 @default.
• W2274981103 cites W1981637597 @default.
• W2274981103 cites W1984757170 @default.
• W2274981103 cites W1986724703 @default.
• W2274981103 cites W1987760376 @default.
• W2274981103 cites W1992087342 @default.
• W2274981103 cites W1997866877 @default.
• W2274981103 cites W2001093915 @default.
• W2274981103 cites W2007183482 @default.
• W2274981103 cites W2011335777 @default.
• W2274981103 cites W2012294916 @default.
• W2274981103 cites W2019877561 @default.
• W2274981103 cites W2045123378 @default.
• W2274981103 cites W2055766577 @default.
• W2274981103 cites W2060825622 @default.
• W2274981103 cites W2064367296 @default.
• W2274981103 cites W2077086280 @default.
• W2274981103 cites W2079210306 @default.
• W2274981103 cites W2090035678 @default.
• W2274981103 cites W2098337213 @default.
• W2274981103 cites W2098733695 @default.
• W2274981103 cites W2100975996 @default.
• W2274981103 cites W2105389498 @default.
• W2274981103 cites W2105777398 @default.
• W2274981103 cites W2107865352 @default.
• W2274981103 cites W2123801633 @default.
• W2274981103 cites W2137790671 @default.
• W2274981103 cites W2145995799 @default.
• W2274981103 cites W2154084248 @default.
• W2274981103 cites W2355414042 @default.
• W2274981103 cites W658752870 @default.
• W2274981103 cites W2275014869 @default.
• W2274981103 doi "https://doi.org/10.7150/jca.13396" @default.
• W2274981103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747889" @default.
• W2274981103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26918048" @default.
• W2274981103 hasPublicationYear "2016" @default.
• W2274981103 type Work @default.
• W2274981103 sameAs 2274981103 @default.
• W2274981103 citedByCount "8" @default.
• W2274981103 countsByYear W22749811032017 @default.
• W2274981103 countsByYear W22749811032018 @default.
• W2274981103 countsByYear W22749811032021 @default.
• W2274981103 countsByYear W22749811032022 @default.
• W2274981103 crossrefType "journal-article" @default.
• W2274981103 hasAuthorship W2274981103A5009191874 @default.
• W2274981103 hasAuthorship W2274981103A5036143991 @default.
• W2274981103 hasAuthorship W2274981103A5073015534 @default.
• W2274981103 hasAuthorship W2274981103A5083484723 @default.
• W2274981103 hasAuthorship W2274981103A5086667271 @default.
• W2274981103 hasAuthorship W2274981103A5087792818 @default.
• W2274981103 hasAuthorship W2274981103A5091107907 @default.
• W2274981103 hasBestOaLocation W22749811031 @default.
• W2274981103 hasConcept C104317684 @default.
• W2274981103 hasConcept C121332964 @default.
• W2274981103 hasConcept C121608353 @default.
• W2274981103 hasConcept C140173407 @default.
• W2274981103 hasConcept C150194340 @default.
• W2274981103 hasConcept C153911025 @default.
• W2274981103 hasConcept C185592680 @default.
• W2274981103 hasConcept C190727270 @default.
• W2274981103 hasConcept C33288867 @default.
• W2274981103 hasConcept C41091548 @default.
• W2274981103 hasConcept C502942594 @default.
• W2274981103 hasConcept C530470458 @default.
• W2274981103 hasConcept C54355233 @default.
• W2274981103 hasConcept C54516573 @default.
• W2274981103 hasConcept C62112901 @default.
• W2274981103 hasConcept C62520636 @default.
• W2274981103 hasConcept C86803240 @default.
• W2274981103 hasConceptScore W2274981103C104317684 @default.
• W2274981103 hasConceptScore W2274981103C121332964 @default.
• W2274981103 hasConceptScore W2274981103C121608353 @default.
• W2274981103 hasConceptScore W2274981103C140173407 @default.
• W2274981103 hasConceptScore W2274981103C150194340 @default.
• W2274981103 hasConceptScore W2274981103C153911025 @default.
• W2274981103 hasConceptScore W2274981103C185592680 @default.
• W2274981103 hasConceptScore W2274981103C190727270 @default.
• W2274981103 hasConceptScore W2274981103C33288867 @default.
• W2274981103 hasConceptScore W2274981103C41091548 @default.
• W2274981103 hasConceptScore W2274981103C502942594 @default.
• W2274981103 hasConceptScore W2274981103C530470458 @default.

• next