Matches in SemOpenAlex for { <https://semopenalex.org/work/W2274992988> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2274992988 endingPage "44" @default.
- W2274992988 startingPage "3839" @default.
- W2274992988 abstract "The antitumor effects of N-(4-hydroxyphenyl)retinamide (4-HPR), and its stable C-linked analog, 4-hydroxybenzylretinone (4-HBR) on the regression of established 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary tumors were compared. 4-HBR is a stable and nonhydroyzable derivative which cannot be converted in vivo to retinoic acid (RA). The results indicate that 4-HBR decreased mammary tumor volumes to the same extent as equimolar concentration (2 mmol/kg diet) of 4-HPR (-45% for 4-HBR vs. -42% for 4-HPR, p<0.01). Both 4-HPR and 4-HBR bind very poorly to nuclear retinoid receptors RARs and RXRs. The similarity of physicochemical properties of 4-HPR and 4-HBR as well as their equal antitumor potency suggests that 4-HPR like 4-HBR, is acting directly rather than through hydrolysis to free RA. Treatment with 4-HPR caused an almost 65% decrease in serum retinol levels. These results suggest that 4-HBR may have a significant chemotherapeutic advantage over 4-HPR, as the nonhydrolyzable analog may not cause night blindness which occurs as a significant side effect of 4-HPR usage." @default.
- W2274992988 created "2016-06-24" @default.
- W2274992988 creator A5011656540 @default.
- W2274992988 creator A5047591856 @default.
- W2274992988 creator A5053558865 @default.
- W2274992988 creator A5055161866 @default.
- W2274992988 creator A5055946982 @default.
- W2274992988 creator A5067466700 @default.
- W2274992988 creator A5070524203 @default.
- W2274992988 date "2002-03-26" @default.
- W2274992988 modified "2023-09-23" @default.
- W2274992988 title "Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable C-linked analog of N-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis." @default.
- W2274992988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11911255" @default.
- W2274992988 hasPublicationYear "2002" @default.
- W2274992988 type Work @default.
- W2274992988 sameAs 2274992988 @default.
- W2274992988 citedByCount "4" @default.
- W2274992988 countsByYear W22749929882016 @default.
- W2274992988 countsByYear W22749929882017 @default.
- W2274992988 crossrefType "journal-article" @default.
- W2274992988 hasAuthorship W2274992988A5011656540 @default.
- W2274992988 hasAuthorship W2274992988A5047591856 @default.
- W2274992988 hasAuthorship W2274992988A5053558865 @default.
- W2274992988 hasAuthorship W2274992988A5055161866 @default.
- W2274992988 hasAuthorship W2274992988A5055946982 @default.
- W2274992988 hasAuthorship W2274992988A5067466700 @default.
- W2274992988 hasAuthorship W2274992988A5070524203 @default.
- W2274992988 hasConcept C104317684 @default.
- W2274992988 hasConcept C114246631 @default.
- W2274992988 hasConcept C126322002 @default.
- W2274992988 hasConcept C134018914 @default.
- W2274992988 hasConcept C150903083 @default.
- W2274992988 hasConcept C185592680 @default.
- W2274992988 hasConcept C202751555 @default.
- W2274992988 hasConcept C207001950 @default.
- W2274992988 hasConcept C2775954498 @default.
- W2274992988 hasConcept C2778938436 @default.
- W2274992988 hasConcept C2781121885 @default.
- W2274992988 hasConcept C502942594 @default.
- W2274992988 hasConcept C55493867 @default.
- W2274992988 hasConcept C555283112 @default.
- W2274992988 hasConcept C57992300 @default.
- W2274992988 hasConcept C71240020 @default.
- W2274992988 hasConcept C71924100 @default.
- W2274992988 hasConcept C86803240 @default.
- W2274992988 hasConceptScore W2274992988C104317684 @default.
- W2274992988 hasConceptScore W2274992988C114246631 @default.
- W2274992988 hasConceptScore W2274992988C126322002 @default.
- W2274992988 hasConceptScore W2274992988C134018914 @default.
- W2274992988 hasConceptScore W2274992988C150903083 @default.
- W2274992988 hasConceptScore W2274992988C185592680 @default.
- W2274992988 hasConceptScore W2274992988C202751555 @default.
- W2274992988 hasConceptScore W2274992988C207001950 @default.
- W2274992988 hasConceptScore W2274992988C2775954498 @default.
- W2274992988 hasConceptScore W2274992988C2778938436 @default.
- W2274992988 hasConceptScore W2274992988C2781121885 @default.
- W2274992988 hasConceptScore W2274992988C502942594 @default.
- W2274992988 hasConceptScore W2274992988C55493867 @default.
- W2274992988 hasConceptScore W2274992988C555283112 @default.
- W2274992988 hasConceptScore W2274992988C57992300 @default.
- W2274992988 hasConceptScore W2274992988C71240020 @default.
- W2274992988 hasConceptScore W2274992988C71924100 @default.
- W2274992988 hasConceptScore W2274992988C86803240 @default.
- W2274992988 hasIssue "6A" @default.
- W2274992988 hasLocation W22749929881 @default.
- W2274992988 hasOpenAccess W2274992988 @default.
- W2274992988 hasPrimaryLocation W22749929881 @default.
- W2274992988 hasRelatedWork W1993388884 @default.
- W2274992988 hasRelatedWork W2001298788 @default.
- W2274992988 hasRelatedWork W2014188853 @default.
- W2274992988 hasRelatedWork W2048820480 @default.
- W2274992988 hasRelatedWork W2086516652 @default.
- W2274992988 hasRelatedWork W2141965195 @default.
- W2274992988 hasRelatedWork W2145279099 @default.
- W2274992988 hasRelatedWork W2149842075 @default.
- W2274992988 hasRelatedWork W2155400147 @default.
- W2274992988 hasRelatedWork W2274992988 @default.
- W2274992988 hasVolume "21" @default.
- W2274992988 isParatext "false" @default.
- W2274992988 isRetracted "false" @default.
- W2274992988 magId "2274992988" @default.
- W2274992988 workType "article" @default.