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- W2275107911 abstract "A plethora of signaling cascades is activated upon hyposmotic stimulation of mammalian cells. In Intestine 407 cells, p21Rho as well as tyrosine kinase(s) and PtdIns-3- kinase were found to be a prerequisite for VRAC activation, whereas protein kinase C is likely to be involved in the regulation of a distinct organic osmolyte release pathway. In addition, a number of cellular responses are able to modulate the volume-sensitive anion conductance including Ca2+ mobilization, cytoskeletal re-arrangements and vesicle cycling. The molecular mechanism(s) by which these signaling molecules affect ion channel opening is still fragmentary and detailed investigations into the mode of activation including reconstitution studies are hampered by the current lack of information about the molecular identity of the channel(s) involved. Our observation that at least part of the anion channel activation occurs through their recruitment from intracellular compartments to the plasma membrane now adds intracellular Cl− channels to the list of potential VRAC candidates. Other signaling pathways, like the stress kinases p38 and Jnk as well as the ATP-provoked activation of Erk-1/2, are apparently not involved in channel regulation. Although their physiological role in the RVD response remains to be elucidated, it is tempting to speculate that they may have a function in restoring cellular homeostasis and in maintaining cell viability." @default.
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- W2275107911 date "2004-01-01" @default.
- W2275107911 modified "2023-09-24" @default.
- W2275107911 title "Cell Volume Regulation in Intestinal Epithelial Cells" @default.
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- W2275107911 doi "https://doi.org/10.1007/0-387-23752-6_31" @default.
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