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- W2275152512 abstract "Innate host defenses provide the initial defense against invading pathogens. Defects in these defenses result in recurrent infections with pathogens or with opportunistic microorganisms. Both acquired and congenital deficiencies occur. Acquired defects in the innate defense mechanisms may occur in patients of any age following trauma including surgery, after exposure to radiation or chemotherapeutic drugs, or secondary to other disease processes such as autoimmune disease or cancer. Congenital defects are usually observed early in life and are characterized by reduced numbers or function of white blood cells as well as decreased synthesis of defense-related mediators such as cytokines and chemokines or secretion of immunologically nonspecific reactants including components of the complement system. Patients with these deficits have mutations in one or more genes crucial to the normal functioning of the system." @default.
- W2275152512 created "2016-06-24" @default.
- W2275152512 creator A5030005877 @default.
- W2275152512 date "2016-01-01" @default.
- W2275152512 modified "2023-10-11" @default.
- W2275152512 title "Disorders of the Innate Host Defenses" @default.
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- W2275152512 doi "https://doi.org/10.1016/b978-0-12-398381-7.00031-9" @default.
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