Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275189791> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2275189791 abstract "Liver fibrosis develops when chronic liver injury stimulates cells in the liver to produce mediators that activate hepatic stellate cells and stimulate them to secrete collagen. Recent studies have shown that the hypoxia-regulated transcription factor, hypoxia-inducible factor-1α (HIF-1α), is essential for upregulation of profibrotic mediators, such as platelet-derived growth factor (PDGF), in the liver during the development of liver fibrosis. What remains unknown, however, is the cell type-specific regulation of profibrotic mediators by HIFs. Accordingly, in the present study the hypothesis was tested that HIFs regulate production of profibrotic mediators by hypoxic Kupffer cells. Exposure of Kupffer cells isolated from Control mice to 1% oxygen activated HIF-1α, and increased mRNA levels of PDGF-B, vascular endothelial cell growth factor, Angiopoietin-1, and monocyte chemotactic protein-1. Upregulation of all of these mediators by hypoxia was prevented in Kupffer cells isolated from hypoxia-inducible factor-1β-Deficient mice. Results from these studies suggest that HIFs are critical regulators of profibrotic mediator production by hypoxic Kupffer cells. This study was supported by NIH grants DK073566 and RR021940." @default.
- W2275189791 created "2016-06-24" @default.
- W2275189791 creator A5002822941 @default.
- W2275189791 creator A5067628777 @default.
- W2275189791 date "2009-04-01" @default.
- W2275189791 modified "2023-10-14" @default.
- W2275189791 title "Hypoxia‐inducible factor‐dependent production of profibrotic mediators by hypoxic Kupffer cells" @default.
- W2275189791 doi "https://doi.org/10.1096/fasebj.23.1_supplement.117.4" @default.
- W2275189791 hasPublicationYear "2009" @default.
- W2275189791 type Work @default.
- W2275189791 sameAs 2275189791 @default.
- W2275189791 citedByCount "0" @default.
- W2275189791 crossrefType "journal-article" @default.
- W2275189791 hasAuthorship W2275189791A5002822941 @default.
- W2275189791 hasAuthorship W2275189791A5067628777 @default.
- W2275189791 hasConcept C104317684 @default.
- W2275189791 hasConcept C126322002 @default.
- W2275189791 hasConcept C127561419 @default.
- W2275189791 hasConcept C134018914 @default.
- W2275189791 hasConcept C146285616 @default.
- W2275189791 hasConcept C160450060 @default.
- W2275189791 hasConcept C167734588 @default.
- W2275189791 hasConcept C170493617 @default.
- W2275189791 hasConcept C176891718 @default.
- W2275189791 hasConcept C178790620 @default.
- W2275189791 hasConcept C180361614 @default.
- W2275189791 hasConcept C185592680 @default.
- W2275189791 hasConcept C203014093 @default.
- W2275189791 hasConcept C2775960820 @default.
- W2275189791 hasConcept C2777025900 @default.
- W2275189791 hasConcept C2778904781 @default.
- W2275189791 hasConcept C2781294074 @default.
- W2275189791 hasConcept C502942594 @default.
- W2275189791 hasConcept C540031477 @default.
- W2275189791 hasConcept C55493867 @default.
- W2275189791 hasConcept C71924100 @default.
- W2275189791 hasConcept C7836513 @default.
- W2275189791 hasConcept C86803240 @default.
- W2275189791 hasConcept C95444343 @default.
- W2275189791 hasConceptScore W2275189791C104317684 @default.
- W2275189791 hasConceptScore W2275189791C126322002 @default.
- W2275189791 hasConceptScore W2275189791C127561419 @default.
- W2275189791 hasConceptScore W2275189791C134018914 @default.
- W2275189791 hasConceptScore W2275189791C146285616 @default.
- W2275189791 hasConceptScore W2275189791C160450060 @default.
- W2275189791 hasConceptScore W2275189791C167734588 @default.
- W2275189791 hasConceptScore W2275189791C170493617 @default.
- W2275189791 hasConceptScore W2275189791C176891718 @default.
- W2275189791 hasConceptScore W2275189791C178790620 @default.
- W2275189791 hasConceptScore W2275189791C180361614 @default.
- W2275189791 hasConceptScore W2275189791C185592680 @default.
- W2275189791 hasConceptScore W2275189791C203014093 @default.
- W2275189791 hasConceptScore W2275189791C2775960820 @default.
- W2275189791 hasConceptScore W2275189791C2777025900 @default.
- W2275189791 hasConceptScore W2275189791C2778904781 @default.
- W2275189791 hasConceptScore W2275189791C2781294074 @default.
- W2275189791 hasConceptScore W2275189791C502942594 @default.
- W2275189791 hasConceptScore W2275189791C540031477 @default.
- W2275189791 hasConceptScore W2275189791C55493867 @default.
- W2275189791 hasConceptScore W2275189791C71924100 @default.
- W2275189791 hasConceptScore W2275189791C7836513 @default.
- W2275189791 hasConceptScore W2275189791C86803240 @default.
- W2275189791 hasConceptScore W2275189791C95444343 @default.
- W2275189791 hasFunder F4320332161 @default.
- W2275189791 hasIssue "S1" @default.
- W2275189791 hasLocation W22751897911 @default.
- W2275189791 hasOpenAccess W2275189791 @default.
- W2275189791 hasPrimaryLocation W22751897911 @default.
- W2275189791 hasRelatedWork W1998290564 @default.
- W2275189791 hasRelatedWork W2023997632 @default.
- W2275189791 hasRelatedWork W2055544890 @default.
- W2275189791 hasRelatedWork W2067219278 @default.
- W2275189791 hasRelatedWork W2076009955 @default.
- W2275189791 hasRelatedWork W2078283905 @default.
- W2275189791 hasRelatedWork W2097662203 @default.
- W2275189791 hasRelatedWork W2275189791 @default.
- W2275189791 hasRelatedWork W3030944551 @default.
- W2275189791 hasRelatedWork W4254861753 @default.
- W2275189791 hasVolume "23" @default.
- W2275189791 isParatext "false" @default.
- W2275189791 isRetracted "false" @default.
- W2275189791 magId "2275189791" @default.
- W2275189791 workType "article" @default.