Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275193630> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2275193630 abstract "Imaging dopamine receptors with PET and SPECT can shed light on the nature of neuropsychiatric disorders which are characterized by disturbances in dopamine D2/3 receptor functioning. Agonist radioligands are considered superior to antagonists because they are more sensitive to detect dopamine release and may label the D2/3 receptor high-affinity state (D2/3Rhigh) selectively. Only short lived carbon-11 labelled D2/3 agonist tracers are available which can only be used in centers where a cyclotron is present. We aimed therefore to develop D2/3receptor agonist tracers labelled with the longer lived isotopes fluorine-18 or iodine-123. Novel compounds based on an 2-aminomethylchroman-7-ol scaffold incorporating fluorine-19 or iodine-127 in their structure were synthesized. Binding experiments showed that several of them have a high affinity and selectivity for D2/3Rhigh and act as agonists. An iodine containing compound was iodine-123 labelled and showed in biodistribution experiments in rats some specific binding to D2/3 receptors in the striatum, however in storage phosphor imaging experiments no specific binding was found. Several fluorine-containing compounds were fluorine-18 labelled and showed specific binding to D2/3 receptors in the rat striatum in-vitro. However, in-vivo experiments showed that the specific binding to D2/3 receptors in the striatum was relatively low, which prevented starting studies in humans. Nevertheless, further optimization of the chemical structure of our novel compounds can lead to agonist tracers more suitable for in vivo clinical application." @default.
- W2275193630 created "2016-06-24" @default.
- W2275193630 creator A5010231982 @default.
- W2275193630 date "2009-08-01" @default.
- W2275193630 modified "2023-09-23" @default.
- W2275193630 title "Evaluation of Potential Agonist Radioligands for Imaging Dopamine D2/3 Receptors" @default.
- W2275193630 hasPublicationYear "2009" @default.
- W2275193630 type Work @default.
- W2275193630 sameAs 2275193630 @default.
- W2275193630 citedByCount "0" @default.
- W2275193630 crossrefType "journal-article" @default.
- W2275193630 hasAuthorship W2275193630A5010231982 @default.
- W2275193630 hasConcept C120069818 @default.
- W2275193630 hasConcept C120750228 @default.
- W2275193630 hasConcept C134018914 @default.
- W2275193630 hasConcept C160262196 @default.
- W2275193630 hasConcept C170493617 @default.
- W2275193630 hasConcept C185592680 @default.
- W2275193630 hasConcept C199596767 @default.
- W2275193630 hasConcept C202751555 @default.
- W2275193630 hasConcept C2777807558 @default.
- W2275193630 hasConcept C2778938600 @default.
- W2275193630 hasConcept C2780062018 @default.
- W2275193630 hasConcept C44208683 @default.
- W2275193630 hasConcept C513476851 @default.
- W2275193630 hasConcept C55493867 @default.
- W2275193630 hasConcept C67847695 @default.
- W2275193630 hasConcept C86803240 @default.
- W2275193630 hasConcept C98274493 @default.
- W2275193630 hasConceptScore W2275193630C120069818 @default.
- W2275193630 hasConceptScore W2275193630C120750228 @default.
- W2275193630 hasConceptScore W2275193630C134018914 @default.
- W2275193630 hasConceptScore W2275193630C160262196 @default.
- W2275193630 hasConceptScore W2275193630C170493617 @default.
- W2275193630 hasConceptScore W2275193630C185592680 @default.
- W2275193630 hasConceptScore W2275193630C199596767 @default.
- W2275193630 hasConceptScore W2275193630C202751555 @default.
- W2275193630 hasConceptScore W2275193630C2777807558 @default.
- W2275193630 hasConceptScore W2275193630C2778938600 @default.
- W2275193630 hasConceptScore W2275193630C2780062018 @default.
- W2275193630 hasConceptScore W2275193630C44208683 @default.
- W2275193630 hasConceptScore W2275193630C513476851 @default.
- W2275193630 hasConceptScore W2275193630C55493867 @default.
- W2275193630 hasConceptScore W2275193630C67847695 @default.
- W2275193630 hasConceptScore W2275193630C86803240 @default.
- W2275193630 hasConceptScore W2275193630C98274493 @default.
- W2275193630 hasLocation W22751936301 @default.
- W2275193630 hasOpenAccess W2275193630 @default.
- W2275193630 hasPrimaryLocation W22751936301 @default.
- W2275193630 hasRelatedWork W10383471 @default.
- W2275193630 hasRelatedWork W121380788 @default.
- W2275193630 hasRelatedWork W1505952018 @default.
- W2275193630 hasRelatedWork W2026315825 @default.
- W2275193630 hasRelatedWork W2026558631 @default.
- W2275193630 hasRelatedWork W2026642874 @default.
- W2275193630 hasRelatedWork W2028841062 @default.
- W2275193630 hasRelatedWork W2046358424 @default.
- W2275193630 hasRelatedWork W2082842533 @default.
- W2275193630 hasRelatedWork W2084275864 @default.
- W2275193630 hasRelatedWork W2101824682 @default.
- W2275193630 hasRelatedWork W2122843408 @default.
- W2275193630 hasRelatedWork W2134909191 @default.
- W2275193630 hasRelatedWork W2222647220 @default.
- W2275193630 hasRelatedWork W2280262060 @default.
- W2275193630 hasRelatedWork W2363783659 @default.
- W2275193630 hasRelatedWork W2976080574 @default.
- W2275193630 hasRelatedWork W3026416224 @default.
- W2275193630 hasRelatedWork W3043789924 @default.
- W2275193630 hasRelatedWork W342236648 @default.
- W2275193630 isParatext "false" @default.
- W2275193630 isRetracted "false" @default.
- W2275193630 magId "2275193630" @default.
- W2275193630 workType "article" @default.