Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275196661> ?p ?o ?g. }
- W2275196661 endingPage "42" @default.
- W2275196661 startingPage "34" @default.
- W2275196661 abstract "Adverse early life experience is prominent risk factors for numerous psychiatric illnesses, including mood and anxiety disorders. It imposes serious long-term costs on the individual as well as health and social systems. Hence, developing therapies that prevent the long-term consequences of early life stress is of utmost importance, and necessitates a better understanding of the mechanisms by which early life stress triggers long-lasting alterations in gene expression and behavior. Post-weaning isolation rearing of rodents models the behavioral consequences of adverse early life experiences in humans and it is reported to cause anxiety like behavior which is more common in case of females. Therefore, in the present study, we have studied the impact of social isolation of young female mice for 8weeks on the anxiety like behavior and the underlying molecular mechanism. Elevated plus maze and open field test revealed that social isolation caused anxiety like behavior. BDNF, a well-known molecule implicated in the anxiety like behavior, was up-regulated both at the message and protein level in cerebral cortex by social isolation. CREB-1 and CBP, which play a crucial role in BDNF transcription, were up-regulated at mRNA level in cerebral cortex by social isolation. HDAC-2, which negatively regulates BDNF expression, was down-regulated at mRNA and protein level in cerebral cortex by social isolation. Furthermore, BDNF acts in concert with Limk-1, miRNA-132 and miRNA-134 for the regulation of structural and morphological plasticity. Social isolation resulted in up-regulation of Limk-1 mRNA and miRNA-132 expression in the cerebral cortex. MiRNA-134, which inhibits the translation of Limk-1, was decreased in cerebral cortex by social isolation. Taken together, our study suggests that social isolation mediated anxiety like behavior is associated with up-regulation of BDNF expression and concomitant increase in the expression of CBP, CREB-1, Limk-1 and miRNA-132, and decrease in the expression of HDAC-2 and miRNA-134 in the cerebral cortex." @default.
- W2275196661 created "2016-06-24" @default.
- W2275196661 creator A5037675151 @default.
- W2275196661 creator A5052635718 @default.
- W2275196661 creator A5058497190 @default.
- W2275196661 creator A5065242465 @default.
- W2275196661 date "2016-05-01" @default.
- W2275196661 modified "2023-10-14" @default.
- W2275196661 title "Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain" @default.
- W2275196661 cites W1032016924 @default.
- W2275196661 cites W117431324 @default.
- W2275196661 cites W1588326306 @default.
- W2275196661 cites W1680853665 @default.
- W2275196661 cites W1932996150 @default.
- W2275196661 cites W1967075670 @default.
- W2275196661 cites W1968116531 @default.
- W2275196661 cites W1970882922 @default.
- W2275196661 cites W1976571564 @default.
- W2275196661 cites W1987615735 @default.
- W2275196661 cites W1987900652 @default.
- W2275196661 cites W1989053030 @default.
- W2275196661 cites W1992438590 @default.
- W2275196661 cites W1992512706 @default.
- W2275196661 cites W1992529363 @default.
- W2275196661 cites W1998261300 @default.
- W2275196661 cites W2000793737 @default.
- W2275196661 cites W2001863509 @default.
- W2275196661 cites W2003481832 @default.
- W2275196661 cites W2004988279 @default.
- W2275196661 cites W2007835395 @default.
- W2275196661 cites W2009918823 @default.
- W2275196661 cites W2011792474 @default.
- W2275196661 cites W2019522971 @default.
- W2275196661 cites W2022508263 @default.
- W2275196661 cites W2036056969 @default.
- W2275196661 cites W2042609054 @default.
- W2275196661 cites W2050042714 @default.
- W2275196661 cites W2055408622 @default.
- W2275196661 cites W2058625607 @default.
- W2275196661 cites W2069256720 @default.
- W2275196661 cites W2069301915 @default.
- W2275196661 cites W2073692957 @default.
- W2275196661 cites W2073970125 @default.
- W2275196661 cites W2074068251 @default.
- W2275196661 cites W2074801302 @default.
- W2275196661 cites W2075522824 @default.
- W2275196661 cites W2076236287 @default.
- W2275196661 cites W2084658093 @default.
- W2275196661 cites W2085467925 @default.
- W2275196661 cites W2086983843 @default.
- W2275196661 cites W2089551905 @default.
- W2275196661 cites W2090760765 @default.
- W2275196661 cites W2092851101 @default.
- W2275196661 cites W2092923627 @default.
- W2275196661 cites W2113470975 @default.
- W2275196661 cites W2117055846 @default.
- W2275196661 cites W2117530671 @default.
- W2275196661 cites W2118225566 @default.
- W2275196661 cites W2123271440 @default.
- W2275196661 cites W2124453851 @default.
- W2275196661 cites W2127857578 @default.
- W2275196661 cites W2130481778 @default.
- W2275196661 cites W2138473891 @default.
- W2275196661 cites W2143920419 @default.
- W2275196661 cites W2150184392 @default.
- W2275196661 cites W2151674752 @default.
- W2275196661 cites W2160681426 @default.
- W2275196661 cites W2160748820 @default.
- W2275196661 cites W2160869656 @default.
- W2275196661 cites W2162983737 @default.
- W2275196661 cites W2165172518 @default.
- W2275196661 cites W2170684975 @default.
- W2275196661 cites W4211242143 @default.
- W2275196661 cites W9766445 @default.
- W2275196661 doi "https://doi.org/10.1016/j.physbeh.2016.02.032" @default.
- W2275196661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26921097" @default.
- W2275196661 hasPublicationYear "2016" @default.
- W2275196661 type Work @default.
- W2275196661 sameAs 2275196661 @default.
- W2275196661 citedByCount "36" @default.
- W2275196661 countsByYear W22751966612016 @default.
- W2275196661 countsByYear W22751966612017 @default.
- W2275196661 countsByYear W22751966612018 @default.
- W2275196661 countsByYear W22751966612019 @default.
- W2275196661 countsByYear W22751966612020 @default.
- W2275196661 countsByYear W22751966612021 @default.
- W2275196661 countsByYear W22751966612022 @default.
- W2275196661 countsByYear W22751966612023 @default.
- W2275196661 crossrefType "journal-article" @default.
- W2275196661 hasAuthorship W2275196661A5037675151 @default.
- W2275196661 hasAuthorship W2275196661A5052635718 @default.
- W2275196661 hasAuthorship W2275196661A5058497190 @default.
- W2275196661 hasAuthorship W2275196661A5065242465 @default.
- W2275196661 hasConcept C118552586 @default.
- W2275196661 hasConcept C15744967 @default.
- W2275196661 hasConcept C169760540 @default.
- W2275196661 hasConcept C2776893239 @default.
- W2275196661 hasConcept C2777545354 @default.