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- W2275212168 abstract "Breast cancer remains the most common cause of death among middle-aged women in Great Britain and the United States. Asiatic women who have much lower breast-cancer risk have uniformly high rates of urinary estradiol excretion derived largely from the oxidation of estrone and 17beta-estradiol by aryl hydroxylases in the liver and intestine. Caucasian women have a wide range of urinary estriol excretion rates; 20-25% excrete reduced amounts. Recessive mutant genotypes with impairment of estrogen hydroxylation may be the cause. Experiments in Sprague-Dawley rats have shown that estriol is the estrogen giving most active protection against cancers induced by oral 712-dimethylbenzanthracene (DMBA) or procarbazine (PC). Other implanted steroids were not effective. It required more than 60 mcg doses of estradiol monthly to produce a favorable effect. The author recommends clinical testing of preventive estradiol therapy especially in premenopausal Caucasian women with factors indicating greatest risk for breast cancer. Trials have shown that 5 mg daily is well tolerated for at least 11 months." @default.
- W2275212168 created "2016-06-24" @default.
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- W2275212168 date "1973-03-10" @default.
- W2275212168 modified "2023-09-24" @default.
- W2275212168 title "Oestriol and prevention of breast cancer. (Letter to the editor)" @default.
- W2275212168 hasPublicationYear "1973" @default.
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