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• W2275271798 abstract "MERTK-associated retinal degenerations are thought to have defects in phagocytosis of shed outer segment membranes by the retinal pigment epithelium (RPE), as do the rodent models of these diseases. We have subretinally injected an RPE-specific AAV2 vector, AAV2-VMD2-hMERTK, to determine whether this would provide long-term photoreceptor rescue in the RCS rat, which it did for up to 6.5 months, the longest time point examined. Moreover, we found phagosomes in the RPE in the rescued regions of RCS retinas soon after the onset of light. The same vector also had a major protective effect in Mertk-null mice, with a concomitant increase in ERG response amplitudes in the vector-injected eyes. These findings suggest that planned clinical trials with this vector will have a favorable outcome." @default.
• W2275271798 created "2016-06-24" @default.
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• W2275271798 date "2015-10-02" @default.
• W2275271798 modified "2023-09-26" @default.
• W2275271798 title "Gene Therapy for MERTK-Associated Retinal Degenerations" @default.
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• W2275271798 doi "https://doi.org/10.1007/978-3-319-17121-0_65" @default.
• W2275271798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4942279" @default.
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