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• W2275280468 abstract "In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations." @default.
• W2275280468 created "2016-06-24" @default.
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• W2275280468 date "2016-01-27" @default.
• W2275280468 modified "2023-09-26" @default.
• W2275280468 title "<i>EGFR</i>-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma" @default.
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• W2275280468 doi "https://doi.org/10.18632/oncotarget.7029" @default.
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