FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275281946> ?p ?o ?g. }

• W2275281946 endingPage "339" @default.
• W2275281946 startingPage "339" @default.
• W2275281946 abstract "Dose comparison of conivaptan (Vaprisol®) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics Biff F Palmer,1 Amy D Rock,2 Emily J Woodward2 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 2Department of Research and Development, Cumberland Pharmaceuticals Inc., Nashville, TN, USA Purpose: This study aimed to evaluate the efficacy, safety, and pharmacokinetics of 20 and 40 mg/day conivaptan (Vaprisol®) in patients with hypervolemic or euvolemic hyponatremia. Methods: Hyponatremic patients – serum sodium (sNa) ≤130 mEq/L – received either 20 or 40 mg/day of conivaptan for 4 days, following an initial 20 mg loading dose. Efficacy was evaluated by the magnitude and extent of change in sNa. Safety was evaluated by the incidence of adverse events, changes in vital signs and laboratory parameters, rate of sNa correction, and frequency of infusion-site reactions. Pharmacokinetic parameters were also measured. Results: A total of 37 patients received 20 mg/day and 214 patients received 40 mg/day conivaptan. Baseline-adjusted sNa-area under the concentration–time curve increased by an average of 753.8±499.9 mEq·hr/L (20 mg/day) and 689.2±417.3 mEq·hr/L (40 mg/day) over the course of the 4-day treatment period. The majority of patients in both treatment groups achieved a 4 mEq/L increase in sNa over baseline in ~24 hours (82.5%). Average increase in sNa after 4 days was ~10 mEq/L, varying with dosage level and baseline volume status. Treatment success (normal sNa or increase of ≥6 mEq/L) was attained by 70.3% of patients in the 20 mg/day group and 72.0% in the 40 mg/day group. Conclusion: Both 20 and 40 mg/day doses of conivaptan are efficacious in increasing sNa over 4 days of treatment with no observed increase in the frequency of adverse events or specific infusion-site reactions using the higher dose. The pharmacokinetic parameters of both doses were similar to what has been reported previously, exhibiting greater-than-dose-proportional plasma concentrations. Keywords: critical care, electrolyte, SIADH, V2 receptor antagonist, thiazide, osmotic demyelination syndrome" @default.
• W2275281946 created "2016-06-24" @default.
• W2275281946 creator A5011687909 @default.
• W2275281946 creator A5034752446 @default.
• W2275281946 creator A5071613758 @default.
• W2275281946 date "2016-01-01" @default.
• W2275281946 modified "2023-10-18" @default.
• W2275281946 title "Dose comparison of conivaptan (Vaprisol®) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics" @default.
• W2275281946 cites W1527798928 @default.
• W2275281946 cites W1907086383 @default.
• W2275281946 cites W1976053112 @default.
• W2275281946 cites W1976714831 @default.
• W2275281946 cites W1988476274 @default.
• W2275281946 cites W2015522147 @default.
• W2275281946 cites W2037211180 @default.
• W2275281946 cites W2039891108 @default.
• W2275281946 cites W2042129971 @default.
• W2275281946 cites W2065336867 @default.
• W2275281946 cites W2080685753 @default.
• W2275281946 cites W2101582830 @default.
• W2275281946 cites W2110350096 @default.
• W2275281946 cites W2114676903 @default.
• W2275281946 cites W2142268668 @default.
• W2275281946 cites W2142545726 @default.
• W2275281946 cites W2149395743 @default.
• W2275281946 cites W2326342202 @default.
• W2275281946 cites W2401081200 @default.
• W2275281946 cites W2605421222 @default.
• W2275281946 cites W2944874615 @default.
• W2275281946 cites W4241930187 @default.
• W2275281946 doi "https://doi.org/10.2147/dddt.s95326" @default.
• W2275281946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4723016" @default.
• W2275281946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26848258" @default.
• W2275281946 hasPublicationYear "2016" @default.
• W2275281946 type Work @default.
• W2275281946 sameAs 2275281946 @default.
• W2275281946 citedByCount "4" @default.
• W2275281946 countsByYear W22752819462017 @default.
• W2275281946 countsByYear W22752819462018 @default.
• W2275281946 countsByYear W22752819462019 @default.
• W2275281946 countsByYear W22752819462023 @default.
• W2275281946 crossrefType "journal-article" @default.
• W2275281946 hasAuthorship W2275281946A5011687909 @default.
• W2275281946 hasAuthorship W2275281946A5034752446 @default.
• W2275281946 hasAuthorship W2275281946A5071613758 @default.
• W2275281946 hasBestOaLocation W22752819461 @default.
• W2275281946 hasConcept C112705442 @default.
• W2275281946 hasConcept C120665830 @default.
• W2275281946 hasConcept C121332964 @default.
• W2275281946 hasConcept C126322002 @default.
• W2275281946 hasConcept C194828623 @default.
• W2275281946 hasConcept C197934379 @default.
• W2275281946 hasConcept C2776703092 @default.
• W2275281946 hasConcept C2776890885 @default.
• W2275281946 hasConcept C42219234 @default.
• W2275281946 hasConcept C61511704 @default.
• W2275281946 hasConcept C71924100 @default.
• W2275281946 hasConceptScore W2275281946C112705442 @default.
• W2275281946 hasConceptScore W2275281946C120665830 @default.
• W2275281946 hasConceptScore W2275281946C121332964 @default.
• W2275281946 hasConceptScore W2275281946C126322002 @default.
• W2275281946 hasConceptScore W2275281946C194828623 @default.
• W2275281946 hasConceptScore W2275281946C197934379 @default.
• W2275281946 hasConceptScore W2275281946C2776703092 @default.
• W2275281946 hasConceptScore W2275281946C2776890885 @default.
• W2275281946 hasConceptScore W2275281946C42219234 @default.
• W2275281946 hasConceptScore W2275281946C61511704 @default.
• W2275281946 hasConceptScore W2275281946C71924100 @default.
• W2275281946 hasLocation W22752819461 @default.
• W2275281946 hasLocation W22752819462 @default.
• W2275281946 hasLocation W22752819463 @default.
• W2275281946 hasLocation W22752819464 @default.
• W2275281946 hasOpenAccess W2275281946 @default.
• W2275281946 hasPrimaryLocation W22752819461 @default.
• W2275281946 hasRelatedWork W1580426574 @default.
• W2275281946 hasRelatedWork W1971529982 @default.
• W2275281946 hasRelatedWork W2089620537 @default.
• W2275281946 hasRelatedWork W2275480158 @default.
• W2275281946 hasRelatedWork W2323950372 @default.
• W2275281946 hasRelatedWork W2371214482 @default.
• W2275281946 hasRelatedWork W2738845524 @default.
• W2275281946 hasRelatedWork W2929987155 @default.
• W2275281946 hasRelatedWork W3095306390 @default.
• W2275281946 hasRelatedWork W4238089809 @default.
• W2275281946 isParatext "false" @default.
• W2275281946 isRetracted "false" @default.
• W2275281946 magId "2275281946" @default.
• W2275281946 workType "article" @default.